DeepAffinity: Interpretable Deep Learning of Compound-Protein Affinity through Unified Recurrent and Convolutional Neural Networks

Kavli Affiliate: Kyle Shen | First 5 Authors: Mostafa Karimi, Mostafa Karimi, , , | Summary: Motivation: Drug discovery demands rapid quantification of compound-protein interaction (CPI). However, there is a lack of methods that can predict compound-protein affinity from sequences alone with high applicability, accuracy, and interpretability. Results: We present a seamless integration of domain […]


Continue.. DeepAffinity: Interpretable Deep Learning of Compound-Protein Affinity through Unified Recurrent and Convolutional Neural Networks

Compressive Light Field Reconstructions using Deep Learning

Kavli Affiliate: Alyosha Molnar | Summary:Light field imaging is limited in its computational processing demands of high sampling for both spatial and angular dimensions. Single-shot light field cameras sacrifice spatial resolution to sample angular viewpoints, typically by multiplexing incoming rays onto a 2D sensor array. While this resolution can be recovered using compressive sensing, these […]


Continue.. Compressive Light Field Reconstructions using Deep Learning

Computation of a Theoretical Membrane Phase Diagram, and the Role of Phase in Lipid Raft-Mediated Protein Organization

Kavli Affiliate: Barbara Baird | Summary:Lipid phase heterogeneity in the plasma membrane is thought to be crucial for many aspects of cell signaling, but the physical basis of participating membrane domains such as "lipid rafts" remains controversial. Here we consider a lattice model yielding a phase diagram that includes several states proposed to be relevant […]


Continue.. Computation of a Theoretical Membrane Phase Diagram, and the Role of Phase in Lipid Raft-Mediated Protein Organization

Deep convolutional neural networks for segmenting 3D in vivo multiphoton images of vasculature in Alzheimer disease mouse models

Kavli Affiliate: Chris B. Schaffer | Summary:The health and function of tissue rely on its vasculature network to provide reliable blood perfusion. Volumetric imaging approaches, such as multiphoton microscopy, are able to generate detailed 3D images of blood vessels that could contribute to our understanding of the role of vascular structure in normal physiology and […]


Continue.. Deep convolutional neural networks for segmenting 3D in vivo multiphoton images of vasculature in Alzheimer disease mouse models

On the Yau-Tian-Donaldson conjecture for singular Fano varieties

Kavli Affiliate: Zhiting Tian | First 5 Authors: Chi Li, Chi Li, , , | Summary: We prove the Yau-Tian-Donaldson’s conjecture for any $mathbbQ$-Fano variety that has a log smooth resolution of singularities such that the discrepancies of all exceptional divisors are non-positive. In other words, if such a Fano variety is K-polystable, then it […]


Continue.. On the Yau-Tian-Donaldson conjecture for singular Fano varieties

Interval Functions and their Integrals, by Ralph Henstock, Ph.D. thesis, 1948

Kavli Affiliate: Daniel Ralph | First 5 Authors: Ralph Henstock, Ralph Henstock, , , | Summary: Ralph Henstock (1923 – 2007) worked in non-absolute integration, including the Riemann-complete or gauge integral which, independently, Jaroslav Kurzweil also discovered in the 1950’s. As a Cambridge undergraduate Henstock took a course of lectures, by J.C. Burkill, on the […]


Continue.. Interval Functions and their Integrals, by Ralph Henstock, Ph.D. thesis, 1948

Valley-spin polarized Landau levels in a monolayer semiconductor

Kavli Affiliate: Jie Shan | First 5 Authors: Zefang Wang, Zefang Wang, , , | Summary: Electrons in monolayer transition metal dichalcogenides (TMDs) possess both the valley and spin degree of freedom. These internal quantum degrees of freedom have provided an ideal laboratory for exploring both new physical phenomena and electronics and photonics applications. Valley- […]


Continue.. Valley-spin polarized Landau levels in a monolayer semiconductor

Valley-spin polarized Landau levels in a monolayer semiconductor

Kavli Affiliate: Jie Shan | First 5 Authors: Zefang Wang, Zefang Wang, , , | Summary: Electrons in monolayer transition metal dichalcogenides (TMDs) possess both the valley and spin degree of freedom. These internal quantum degrees of freedom have provided an ideal laboratory for exploring both new physical phenomena and electronics and photonics applications. Valley- […]


Continue.. Valley-spin polarized Landau levels in a monolayer semiconductor

GHz-Band Integrated Magnetic Inductors

Kavli Affiliate: Amal El-Ghazaly | Summary:The demand on mobile electronics to continue to shrink in size while increase in efficiency drives the demand on the internal passive components to do the same. Power amplifiers require inductors with small form factors, high quality factors, and high operating frequency in the single-digit GHz range. This work explores […]


Continue.. GHz-Band Integrated Magnetic Inductors

Support points

Kavli Affiliate: Kinfai Mak | First 5 Authors: Simon Mak, Simon Mak, , , | Summary: This paper introduces a new way to compact a continuous probability distribution $F$ into a set of representative points called support points. These points are obtained by minimizing the energy distance, a statistical potential measure initially proposed by SzĂ©kely […]


Continue.. Support points