Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson′s disease

Posted by dbos Yale

Kavli Affiliate: Michael J Higley | Authors: Saroj Sah, Andrew D Sauerbeck, Jyoti Gupta, Dayana Pérez-Acuña, Jacob E Reiber, Dreson Russell, Thomas Goralski, Michael Henderson, Laura A Volpicelli-Daley, Michael J Higley, Terrance T Kummer and Thomas Biederer | Summary: Cognitive impairment is a frequent non-motor symptom in Parkinson’s disease, and cortical Lewy pathology is strongly […]


Continue.. Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson′s disease

Early Galaxies and Early Dark Energy: A Unified Solution to the Hubble Tension and Puzzles of Massive Bright Galaxies revealed by JWST

Posted by dbos MIT

Kavli Affiliate: Mark Vogelsberger | First 5 Authors: Xuejian Shen, Mark Vogelsberger, Michael Boylan-Kolchin, Sandro Tacchella, Rohan P. Naidu | Summary: JWST has revealed a large population of ultra-violet (UV)-bright galaxies at $zgtrsim 10$ and possibly overly massive galaxies at $zgtrsim 7$, challenging standard galaxy formation models in the $Lambda$CDM cosmology. We use an empirical […]


Continue.. Early Galaxies and Early Dark Energy: A Unified Solution to the Hubble Tension and Puzzles of Massive Bright Galaxies revealed by JWST

FlowBench: Revisiting and Benchmarking Workflow-Guided Planning for LLM-based Agents

Posted by dbos Peking

Kavli Affiliate: Ke Wang | First 5 Authors: Ruixuan Xiao, Wentao Ma, Ke Wang, Yuchuan Wu, Junbo Zhao | Summary: LLM-based agents have emerged as promising tools, which are crafted to fulfill complex tasks by iterative planning and action. However, these agents are susceptible to undesired planning hallucinations when lacking specific knowledge for expertise-intensive tasks. […]


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Capture Point Control in Thruster-Assisted Bipedal Locomotion

Posted by dbos Caltech

Kavli Affiliate: Morteza Gharib | First 5 Authors: Shreyansh Pitroda, Aditya Bondada, Kaushik Venkatesh Krishnamurthy, Adarsh Salagame, Chenghao Wang | Summary: Despite major advancements in control design that are robust to unplanned disturbances, bipedal robots are still susceptible to falling over and struggle to negotiate rough terrains. By utilizing thrusters in our bipedal robot, we […]


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Ancient midbrain inhibitory neurons control selective spatial attention

Posted by dbos Hopkins

Kavli Affiliate: Shreesh P. Mysore | Authors: Ninad B Kothari, Wen-Kai You, Arunima Banerjee, Qingcheng Zhang and Shreesh P Mysore | Summary: Animal behavior at any instant is guided by information from only a subset of the plethora of stimuli in their sensory environments. The neural circuit mechanisms that select a behaviorally relevant ‘target’ from […]


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Growth of high redshift supermassive black holes from heavy seeds in the BRAHMA cosmological simulations: Implications of overmassive black holes

Posted by dbos MIT

Kavli Affiliate: Mark Vogelsberger | First 5 Authors: Aklant K Bhowmick, Laura Blecha, Paul Torrey, Rachel S Somerville, Luke Zoltan Kelley | Summary: JWST has recently revealed a large population of accreting black holes (BHs) in the early Universe. Even after accounting for possible systematic biases, the high-z $M_*-M_{rm rm bh}$ relation derived from these […]


Continue.. Growth of high redshift supermassive black holes from heavy seeds in the BRAHMA cosmological simulations: Implications of overmassive black holes

Roman FFP Revolution: Two, Three, Many Plutos

Posted by dbos Peking

Kavli Affiliate: Subo Dong | First 5 Authors: Andrew Gould, Jennifer C. Yee, Subo Dong, , | Summary: Roman microlensing stands at a crossroads between its originally charted path of cataloging a population of cool planets that has subsequently become well-measured down to super-Earths, and the path of free-floating planets (FFPs), which did not exist […]


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The Radius of the High-mass Pulsar PSR J0740+6620 with 3.6 yr of NICER Data

Posted by dbos MIT

Kavli Affiliate: Deepto Chakrabarty | First 5 Authors: Tuomo Salmi, Devarshi Choudhury, Yves Kini, Thomas E. Riley, Serena Vinciguerra | Summary: We report an updated analysis of the radius, mass, and heated surface regions of the massive pulsar PSR J0740+6620 using Neutron Star Interior Composition Explorer (NICER) data from 2018 September 21 to 2022 April […]


Continue.. The Radius of the High-mass Pulsar PSR J0740+6620 with 3.6 yr of NICER Data

The Radius of the High-mass Pulsar PSR J0740+6620 with 3.6 yr of NICER Data

Posted by dbos MIT

Kavli Affiliate: Deepto Chakrabarty | First 5 Authors: Tuomo Salmi, Devarshi Choudhury, Yves Kini, Thomas E. Riley, Serena Vinciguerra | Summary: We report an updated analysis of the radius, mass, and heated surface regions of the massive pulsar PSR J0740+6620 using Neutron Star Interior Composition Explorer (NICER) data from 2018 September 21 to 2022 April […]


Continue.. The Radius of the High-mass Pulsar PSR J0740+6620 with 3.6 yr of NICER Data