Kavli Affiliate: Yi Zhou
| First 5 Authors: Yang Wang, Danni Wang, Liting Zhong, Yi Zhou, Qing Wang
| Summary:
Photoacoustic tomography (PAT) enables non-invasive cross-sectional imaging
of biological tissues, but it fails to map the spatial variation of
speed-of-sound (SOS) within tissues. While SOS is intimately linked to density
and elastic modulus of tissues, the imaging of SOS distri-bution serves as a
complementary imaging modality to PAT. Moreover, an accurate SOS map can be
leveraged to correct for PAT image degradation arising from acoustic
heterogene-ities. Herein, we propose a novel approach for SOS reconstruction
using only PAT imaging modality. Our method is based on photoacoustic reversal
beacons (PRBs), which are small light-absorbing targets with strong
photoacoustic contrast. We excite and scan a number of PRBs positioned at the
periphery of the target, and the generated photoacoustic waves prop-agate
through the target from various directions, thereby achieve spatial sampling of
the internal SOS. We formulate a linear inverse model for pixel-wise SOS
reconstruction and solve it with iterative optimization technique. We validate
the feasibility of the proposed method through simulations, phantoms, and ex
vivo biological tissue tests. Experimental results demonstrate that our
approach can achieve accurate reconstruction of SOS distribu-tion. Leveraging
the obtained SOS map, we further demonstrate significantly enhanced PAT image
reconstruction with acoustic correction.
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