Kavli Affiliate: Gijsje H. Koenderink
| First 5 Authors: James P. Conboy, Irene Istúriz Petitjean, Anouk van der Net, Gijsje H. Koenderink,
| Summary:
Cell migration is a fundamental process for life and is highly dependent on
the dynamical and mechanical properties of the cytoskeleton. Intensive physical
and biochemical crosstalk between actin, microtubules, and intermediate
filaments ensures their coordination to facilitate and enable migration. In
this review we discuss the different mechanical aspects that govern cell
migration and provide, for each mechanical aspect, a novel perspective by
juxtaposing two complementary approaches to the biophysical study of
cytoskeletal crosstalk: live-cell studies (often referred to as top-down
studies) and cell-free studies (often referred to as bottom-up studies). We
summarize the main findings from both experimental approaches, and we provide
our perspective on bridging the two perspectives to address the open questions
of how cytoskeletal crosstalk governs cell migration and makes cells move.
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