Kavli Affiliate: Lihong V. Wang
| First 5 Authors: Yang Zhang, Karteekeya Sastry, Iyla Rossi, Joshua Olick-Gibson, Jonathan J. Russin
| Summary:
Noninvasive imaging deep into the adult brain at submillimeter and
millisecond scales remains a challenge in medical imaging. Here, we report a
helmet based ultrasound brain imager built from a customized helmet, a scanned
ultrasound array, and three dimensional printing for real time imaging of human
brain anatomical and functional information. Through its application to post
hemicraniectomy patients in a sitting position, we achieved volumetric brain
tissue structural, vascular, and blood flow images at centimeter scale depths
with submillimeter and millisecond spatiotemporal resolutions. We also
demonstrated the system capability to track cerebral blood flow over repeated
imaging sessions, including during motion prone conditions. Our brain imager
circumvents the skull and bridges the gap between high resolution human brain
imaging and wearable convenience. This imager may serve as a platform for
further investigations into human brain dynamics in post hemicraniectomy
patients and offer insights into the brain that could surpass those obtained
from non human primate studies.
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