An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Matthew A Cattle, Lauren C Aguado, Samantha Sze, Dylan Yueyang Wang, Thales Papagiannakopoulos, Susan Smith, Charles M Rice, William Matthew Schneider and John T Poirier | Summary: Retrons are a retroelement class found in diverse prokaryotes that can be adapted to augment CRISPR-Cas9 genome engineering technology to efficiently […]


Continue.. An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks

Dark Matter Velocity Distributions for Direct Detection: Astrophysical Uncertainties are Smaller Than They Appear

Posted by klaurent MIT

Kavli Affiliate: Lina Necib | Summary:The sensitivity of direct detection experiments depends on the phase-space distribution of dark matter near the Sun, which can be modeled theoretically using cosmological hydrodynamical simulations of Milky Way-like galaxies. However, capturing the halo-to-halo variation in the local dark matter speeds — a necessary step for quantifying the astrophysical uncertainties […]


Continue.. Dark Matter Velocity Distributions for Direct Detection: Astrophysical Uncertainties are Smaller Than They Appear

Dark Matter Velocity Distributions for Direct Detection: Astrophysical Uncertainties are Smaller Than They Appear

Posted by dbos MIT

Kavli Affiliate: Lina Necib | First 5 Authors: Dylan Folsom, Carlos Blanco, Mariangela Lisanti, Lina Necib, Mark Vogelsberger | Summary: The sensitivity of direct detection experiments depends on the phase-space distribution of dark matter near the Sun, which can be modeled theoretically using cosmological hydrodynamical simulations of Milky Way-like galaxies. However, capturing the halo-to-halo variation […]


Continue.. Dark Matter Velocity Distributions for Direct Detection: Astrophysical Uncertainties are Smaller Than They Appear

ABS-Mamba: SAM2-Driven Bidirectional Spiral Mamba Network for Medical Image Translation

Posted by klaurent Peking

Kavli Affiliate: Feng Yuan | First 5 Authors: Feng Yuan, Feng Yuan, , , | Summary: Accurate multi-modal medical image translation requires ha-rmonizing global anatomical semantics and local structural fidelity, a challenge complicated by intermodality information loss and structural distortion. We propose ABS-Mamba, a novel architecture integrating the Segment Anything Model 2 (SAM2) for organ-aware […]


Continue.. ABS-Mamba: SAM2-Driven Bidirectional Spiral Mamba Network for Medical Image Translation

ABS-Mamba: SAM2-Driven Bidirectional Spiral Mamba Network for Medical Image Translation

Posted by dbos Peking

Kavli Affiliate: Feng Yuan | First 5 Authors: Feng Yuan, Yifan Gao, Wenbin Wu, Keqing Wu, Xiaotong Guo | Summary: Accurate multi-modal medical image translation requires ha-rmonizing global anatomical semantics and local structural fidelity, a challenge complicated by intermodality information loss and structural distortion. We propose ABS-Mamba, a novel architecture integrating the Segment Anything Model […]


Continue.. ABS-Mamba: SAM2-Driven Bidirectional Spiral Mamba Network for Medical Image Translation

EP241021a: a months-duration X-ray transient with luminous optical and radio emission

Posted by klaurent Stanford

Kavli Affiliate: Paul Brink| First 5 Authors: Shu Xinwen, Shu Xinwen, , , | Summary:We present the discovery of a peculiar X-ray transient, EP241021a, by the Einstein Probe (EP) mission, and the results from multiwavelength follow-up observations. The transient was first detected with the Wide-field X-ray Telescope as an intense flare lasting for ~100 s, […]


Continue.. EP241021a: a months-duration X-ray transient with luminous optical and radio emission

Weak transcription factor clustering at binding sites can facilitate information transfer from molecular signals

Posted by klaurent Delft

Kavli Affiliate: Jos Zwanikken | Summary:Transcription factor concentrations provide signals to cells that allow them to regulate gene expression to make correct cell fate decisions. Calculations for noise bounds in gene regulation suggest that clustering or cooperative binding of transcription factors decreases signal-to-noise ratios at binding sites. However, clustering of transcription factor molecules around binding […]


Continue.. Weak transcription factor clustering at binding sites can facilitate information transfer from molecular signals

Rapid formation of a very massive star >50000 $M_odot$ and subsequently an IMBH from runaway collisions. Direct N-body and Monte Carlo simulations of dense star clusters

Posted by klaurent Peking

Kavli Affiliate: Rainer Spurzem | Summary:Context. We present simulations of a massive young star cluster using textscNbody6++GPU and textscMOCCA. The cluster is initially more compact than previously published models, with one million stars, a total mass of $5.86 times 10^5~mathrmM_odot$, and a half-mass radius of $0.1~mathrmpc$. Aims. We analyse the formation and growth of a […]


Continue.. Rapid formation of a very massive star >50000 $M_odot$ and subsequently an IMBH from runaway collisions. Direct N-body and Monte Carlo simulations of dense star clusters