Kavli Affiliate: Lihong V. Wang
| First 5 Authors: Yousuf Aborahama, Karteekeya Sastry, Manxiu Cui, Yang Zhang, Yilin Luo
| Summary:
Noninvasive transcranial photoacoustic computed tomography (PACT) of the
human brain, despite its clinical potential as a complementary technology to
functional MRI, remains impeded by the acoustic distortion induced by the human
skull. The distortion, which is attributed to the markedly different material
properties of the skull relative to soft tissue, results in heavily aberrated
PACT images — a problem that has remained unsolved for the past two decades.
Herein, we report the first successful experimental demonstration of the
de-aberration of PACT images through an ex-vivo adult human skull using a
homogeneous elastic model for the skull. Using only the geometry, position, and
orientation of the skull, we faithfully de-aberrate the PACT images of
light-absorbing phantoms acquired through an ex-vivo human skull for different
levels of phantom complexity and positions. We also demonstrate the generality
of our results by attaining a similar extent of de-aberration through a second
ex-vivo human skull. Our work addresses the longstanding challenge of
skull-induced aberrations in transcranial PACT and advances the field towards
unlocking the full potential of transcranial human brain PACT.
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