Kavli Affiliate: Gijsje H. Koenderink
| First 5 Authors: Ruben C. Boot, Anouk van der Net, Christos Gogou, Pranav Mehta, Dimphna H. Meijer
| Summary:
Tissue surface tension influences cell sorting and tissue fusion. Earlier
mechanical studies suggest that multicellular spheroids actively reinforce
their surface tension with applied force. Here we study this open question
through high-throughput microfluidic micropipette aspiration measurements on
cell spheroids to identify the role of force duration and cell contractility.
We find that larger spheroid deformations lead to faster cellular retraction
once the pressure is released, regardless of the applied force and cellular
contractility. These new insights demonstrate that spheroid viscoelasticity is
deformation-dependent and challenge whether surface tension truly reinforces.
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