Kavli Affiliate: Stefano Fusi & Mazen Kheirbek
| Authors: Frances Xia, Valeria Fascianelli, Nina Vishwakarma, Frances Grace Ghinger, Stefano Fusi and Mazen Kheirbek
| Summary:
The neural dynamics that underlie divergent anhedonic responses to stress remain unclear. Here, we identified neuronal dynamics in an amygdala-hippocampal circuit that distinguish stress resilience and susceptibility. In a reward-choice task, basolateral amygdala (BLA) activity in resilient mice showed enhanced discrimination of upcoming reward choices. In contrast, a rumination-like signature emerged in the BLA of susceptible mice; a linear decoder could classify the intention to switch or stay on a previously chosen reward. Spontaneous activity in the BLA of susceptible mice was higher dimensional than controls, reflecting the exploration of a larger number of distinct neural states. Manipulation of vCA1-BLA inputs rescued dysfunctional neural dynamics and anhedonia in susceptible mice, suggesting that targeting this pathway can enhance BLA circuit function and ameliorate of depression-related behaviors. One-Sentence Summary Identification and rescue of dysfunctional vCA1-BLA population dynamics and behavior in stress-susceptible mice.