Kavli Affiliate: Philip Starr
| Authors: Bahman Abdi-Sargezeh, Sepehr Shirani, Abhinav Sharma, Philip Starr, Simon Little and Ashwini Oswal
| Summary:
Neural activities within the beta frequency range (13-30 Hz) are not stationary, but occur in transient packets known as beta bursts. Parkinson’s disease (PD) is characterized by the occurrence of beta bursts of increased duration and amplitude within the cortico-basal ganglia network. The pathophysiological importance of beta bursts is exemplified by the fact that they serve as a clinically useful feedback signal in beta amplitude triggered adaptive Deep Brain Stimulation (aDBS). Prolonged duration beta bursts are closely associated with motor impairments in PD, whilst bursts of shorter duration may have a physiological role. Consequently, we aimed to develop a deep learning-based pipeline capable of predicting long (>150ms) and short (<150ms) duration beta bursts from subthalamic nucleus local field potential (LFP) recordings. Our approach achieved promising accuracy values of 87% and 85.2% in two patients implanted with a DBS device that was capable of long-term wireless LFP sensing. Our findings highlight the feasibility of prolonged beta burst prediction and could inform the development of a new type of intelligent DBS approach with the capability of delivering stimulation only during the occurrence of prolonged bursts.