Reduced progranulin increases tau and α-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Sanaea Bhagwagar, Sarah H. Nies, Marius T. Chiasseu, Guilin Wang, Ian R. Mackenzie and Stephen M. Strittmatter | Summary: Comorbid proteinopathies are observed in many neurodegenerative disorders including Alzheimer’s disease (AD), increase with age, and influence clinical outcomes, yet the mechanisms remain ill-defined. Here, we show that […]


Continue.. Reduced progranulin increases tau and α-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase