Kavli Affiliate: Paul W. Sternberg
| First 5 Authors: Shuo Pang, Chao Han, Mihoko Kato, Paul W. Sternberg, Changhuei Yang
| Summary:
The fluorescence microscope is one of the most important tools in modern
clinical diagnosis and biological science. However, its expense, size and
limited field-of-view (FOV) are becoming bottlenecks in key applications such
as large-scale phenotyping and low-resource-setting diagnostics. Here we report
a low-cost, compact chip-scale fluorescence-imaging platform, termed the
Fluorescence Talbot Microscopy (FTM), which utilizes the Talbot self-imaging
effect to enable efficient fluorescence imaging over a large and
directly-scalable FOV. The FTM prototype has a resolution of 1.2 microns and an
FOV of 3.9 mm x 3.5 mm. We demonstrate the imaging capability of FTM on
fluorescently labeled breast cancer cells (SK-BR-3) and HEK cells expressing
green fluorescent protein.
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