Kavli Affiliate: Martin Depken | Summary:Both genomic stability and sustenance of day-to-day life rely on efficient and accurate readout of the genetic code. Single-molecule experiments show that transcription and replication are highly stochastic and irregular processes, with the polymerases frequently pausing and even reversing direction. While such behavior is recognized as stemming from a sophisticated […]
Continue.. Irregular transcription dynamics for rapid production of high-fidelity transcripts