Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death during Mammary Gland Involution

Kavli Affiliate: Shawn Ferguson | Authors: Jaekwang Jeong, Jongwon Lee, Gabriel Talaia, Wonnam Kim, Junho Song, Kwangmin Yoo, David G. Gonzalez, Diana Athonvarangkul, Jaehun Shin, Pamela Dann, Ann M Haberman, Lark Kyun Kim, Shawn M. Ferguson, Jungmin Choi and John Wysolmerski | Summary: Involution of the mammary gland after lactation is a dramatic example of […]


Continue.. Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death during Mammary Gland Involution

Clonally selected lines after CRISPR/Cas editing are not isogenic

Kavli Affiliate: Robert Edwards | Authors: Michael J. Roach, Sarah Beecroft, Kathie Mihindukulasuriya, Leran Wang, Lais Farias Oliveira Lima, Elizabeth A. Dinsdale, Robert Edwards and Scott Allyn Handley | Summary: The CRISPR-Cas9 system has enabled researchers to precisely modify/edit the sequence of a genome. A typical editing experiment consists of two steps: (i) editing cultured […]


Continue.. Clonally selected lines after CRISPR/Cas editing are not isogenic

Flexible perceptual encoding by discrete gamma events

Kavli Affiliate: Jessica Cardin | Authors: Quentin Perrenoud, Antonio H. de O. Fonseca, Austin Airhart, James Bonanno, Rong Mao and Jessica A Cardin | Summary: Although behaviorally relevant patterns of neocortical activity in specific frequency bands have been broadly characterized, identifying individual underlying network events remains a key challenge in understanding information processing in cortical […]


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Scaled-expansion of the membrane associated cytoskeleton requires conserved kinesin adaptors

Kavli Affiliate: Shawn Ferguson | Authors: Oliver Glomb, Grace Swaim, Pablo Munoz LLancao, Christopher Lovejoy, Sabyasachi Sutradhar, Junhyun Park, Youjun Wu, Marc Hammarlund, Jonathon Howard, Shawn M. Ferguson and Shaul Yogev | Summary: A periodic lattice of actin rings and spectrin tetramers scaffolds the axonal membrane. How spectrin is delivered to this structure to scale […]


Continue.. Scaled-expansion of the membrane associated cytoskeleton requires conserved kinesin adaptors

TMEM106B is increased in Multiple Sclerosis plaques, and deletion causes accumulation of lipid after demyelination

Kavli Affiliate: Stephen Strittmatter | Authors: Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C DuBois, John R Corboy, Stephen M. Strittmatter, Hillary Guzik, Sarah Graff and Rashed M Nagra | Summary: During inflammatory, demyelinating diseases such as multiple sclerosis (MS) axonal damage is prevalent early in the disease course. Axonal damage includes swellings, defects […]


Continue.. TMEM106B is increased in Multiple Sclerosis plaques, and deletion causes accumulation of lipid after demyelination

An Integrated Platform for High-Throughput Nanoscopy

Kavli Affiliate: Joerg Bewersdorf | Authors: Andrew E. S. Barentine, Yu Lin, Edward M Courvan, Phylicia Kidd, Miao Liu, Leonhard Balduf, Timy Phan, Felix Rivera-Molina, Michael R. Grace, Zach Marin, Mark Lessard, Juliana Rios-Chen, Siyuan Wang, Karla M Neugebauer, Joerg Bewersdorf and David Baddeley | Summary: Diffraction-unlimited single-molecule techniques like STORM and (F)PALM enable three-dimensional […]


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Connectome-based predictions reveal developmental change in the functional architecture of sustained attention and working memory

Kavli Affiliate: Marvin Chun | Authors: Omid Kardan, Andrew J Stier, Carlos Cardenas-Inigues, Julia C Pruin, Kathryn E Schertz, Yuting Deng, Taylor Chamberlain, Wesley J Meredith, Xihan Zhang, Jilian E Bowman, Tanvi Lakhtakia, Lucy Tindel, Emily W Avery, Qi Lin, Kwangsun Yoo, Marvin M Chun, Marc G Berman and Monica D Rosenberg | Summary: Sustained […]


Continue.. Connectome-based predictions reveal developmental change in the functional architecture of sustained attention and working memory

All-optical visualization of specific molecules in the ultrastructural context of brain tissue

Kavli Affiliate: Joerg Bewersdorf, Pietro DeCamilli | Authors: Ons M’Saad, Ravikiran Kasula, Ilona Kondratiuk, Phylicia Kidd, Hanieh Falahati, Juliana E Gentile, Robert F Niescier, Katherine Watters, Robert C Sterner, Seong Lee, Xinran Liu, Pietro De Camilli, James E Rothman, Anthony J Koleske, Thomas Biederer and Joerg Bewersdorf | Summary: Understanding the molecular anatomy and neural […]


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A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membrane

Kavli Affiliate: Pietro DeCamilli | Authors: Andrés Guillén Samander, Yumei Wu, S. Sebastian Pineda, Francisco J. García, Julia N. Eisen, Marianna Leonzino, Berrak Uğur, Manolis Kellis, Myriam Heiman and Pietro De Camilli | Summary: Chorea-acanthocytosis and McLeod syndrome are diseases with shared clinical manifestations caused by mutations in VPS13A and XK, respectively. Key features of […]


Continue.. A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membrane

ASD modelling in organoids reveals imbalance of excitatory cortical neuron subtypes during early neurogenesis

Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Feinan Wu, Jessica Mariani, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Milovan Suvakov, Jeremy Schreiner, Yeongjun Jang, Cindy Khanh Nguyen, Elise M Cummings, Gloria Han, Kelly Powell, Anna Szekely, James C McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M Vaccarino | Summary: […]


Continue.. ASD modelling in organoids reveals imbalance of excitatory cortical neuron subtypes during early neurogenesis