Kavli Affiliate: Jessica Cardin | Authors: Quentin Perrenoud, Antonio H. de O. Fonseca, Austin Airhart, James Bonanno, Rong Mao and Jessica A Cardin | Summary: Although behaviorally relevant patterns of neocortical activity in specific frequency bands have been broadly characterized, identifying individual underlying network events remains a key challenge in understanding information processing in cortical […]
Kavli Affiliate: Shawn Ferguson | Authors: Oliver Glomb, Grace Swaim, Pablo Munoz LLancao, Christopher Lovejoy, Sabyasachi Sutradhar, Junhyun Park, Youjun Wu, Marc Hammarlund, Jonathon Howard, Shawn M. Ferguson and Shaul Yogev | Summary: A periodic lattice of actin rings and spectrin tetramers scaffolds the axonal membrane. How spectrin is delivered to this structure to scale […]
Kavli Affiliate: Stephen Strittmatter | Authors: Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C DuBois, John R Corboy, Stephen M. Strittmatter, Hillary Guzik, Sarah Graff and Rashed M Nagra | Summary: During inflammatory, demyelinating diseases such as multiple sclerosis (MS) axonal damage is prevalent early in the disease course. Axonal damage includes swellings, defects […]
Kavli Affiliate: Joerg Bewersdorf | Authors: Andrew E. S. Barentine, Yu Lin, Edward M Courvan, Phylicia Kidd, Miao Liu, Leonhard Balduf, Timy Phan, Felix Rivera-Molina, Michael R. Grace, Zach Marin, Mark Lessard, Juliana Rios-Chen, Siyuan Wang, Karla M Neugebauer, Joerg Bewersdorf and David Baddeley | Summary: Diffraction-unlimited single-molecule techniques like STORM and (F)PALM enable three-dimensional […]
Kavli Affiliate: Marvin Chun | Authors: Omid Kardan, Andrew J Stier, Carlos Cardenas-Inigues, Julia C Pruin, Kathryn E Schertz, Yuting Deng, Taylor Chamberlain, Wesley J Meredith, Xihan Zhang, Jilian E Bowman, Tanvi Lakhtakia, Lucy Tindel, Emily W Avery, Qi Lin, Kwangsun Yoo, Marvin M Chun, Marc G Berman and Monica D Rosenberg | Summary: Sustained […]
Kavli Affiliate: Joerg Bewersdorf, Pietro DeCamilli | Authors: Ons M’Saad, Ravikiran Kasula, Ilona Kondratiuk, Phylicia Kidd, Hanieh Falahati, Juliana E Gentile, Robert F Niescier, Katherine Watters, Robert C Sterner, Seong Lee, Xinran Liu, Pietro De Camilli, James E Rothman, Anthony J Koleske, Thomas Biederer and Joerg Bewersdorf | Summary: Understanding the molecular anatomy and neural […]
Kavli Affiliate: Pietro DeCamilli | Authors: Andrés Guillén Samander, Yumei Wu, S. Sebastian Pineda, Francisco J. García, Julia N. Eisen, Marianna Leonzino, Berrak Uğur, Manolis Kellis, Myriam Heiman and Pietro De Camilli | Summary: Chorea-acanthocytosis and McLeod syndrome are diseases with shared clinical manifestations caused by mutations in VPS13A and XK, respectively. Key features of […]
Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Feinan Wu, Jessica Mariani, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Milovan Suvakov, Jeremy Schreiner, Yeongjun Jang, Cindy Khanh Nguyen, Elise M Cummings, Gloria Han, Kelly Powell, Anna Szekely, James C McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M Vaccarino | Summary: […]
Kavli Affiliate: Pietro DeCamilli | Authors: Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E. Greene, Pietro De Camilli and Mian Cao | Summary: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically-enriched clathrin-uncoating factors, synaptojanin 1 (SJ1) and […]
Kavli Affiliate: Pietro DeCamilli | Authors: Shujun Cai, Yumei Wu, Andres Guillen-Samander, William F Hancock-Cerutti, Jun Liu and Pietro De Camilli | Summary: VPS13 is a eukaryotic lipid transport protein localized at membrane contact sites. Previous studies suggested that it may transfer lipids between adjacent bilayers by a bridge-like mechanism. Direct evidence for this hypothesis […]