Kavli Affiliate: Joerg Bewersdorf | Authors: Ons M’Saad, Michael Shribak and Joerg Bewersdorf | Summary: Abstract The spatial resolution and contrast sensitivity of the human eye is limited, restricting our ability to directly see subcellular structures. We report a new principle for unaided eye cellular visualization in a method we call Unclearing Microscopy. By expanding […]
Kavli Affiliate: Elena Gracheva | Authors: Luke H. Ziolkowski, Elena O. Gracheva and Sviatoslav N. Bagriantsev | Summary: Abstract Afferents of peripheral mechanoreceptors innervate the skin of vertebrates, where they detect physical touch via mechanically gated ion channels (mechanotransducers). While the afferent terminal is generally understood to be the primary site of mechanotransduction, the functional […]
Kavli Affiliate: Pasko Rakic, Nenad Sestan | Authors: Nicola Micali, Shaojie Ma, Mingfeng Li, Suel-Kee Kim, Xoel Mato-Blanco, Suvimal Sindhu, Jon I. Arellano, Tianliuyun Gao, Alvaro Duque, Gabriel Santpere, Nenad Sestan and Pasko Rakic | Summary: Abstract Early telencephalic development involves patterning of the distinct regions and fate specification of the neural stem cells (NSCs). […]
Kavli Affiliate: Pietro DeCamilli | Authors: Xinbo Wang, Javier Espadas, Yumei Wu, Shujun Cai, Jinghua Ge, Lin Shao, Aurélien Roux and Pietro De Camilli | Summary: Mutations in Leucine-rich repeat kinase 2 (LRRK2) are responsible for late-onset autosomal dominant Parkinson’s disease (PD). LRRK2 has been implicated in a wide range of physiological processes including membrane […]
Kavli Affiliate: Sreeganga Chandra | Authors: Eduardo Martin-Lopez, Charles A. GREER, Sreeganga Chandra, Vidyadhara D J, Teresa Liberia, Sarah J. Meller, Leah E. Harmon, Ryan M. Hsu, Kimberly Han and Betul Yucel | Summary: Abstract Parkinson’s Disease (PD) is characterized by multiple symptoms including olfactory dysfunction, whose underlying mechanisms remain unclear. Here, we explored pathological […]
Kavli Affiliate: Pietro DeCamilli | Authors: Taryn J. Olivas, Yumei Wu, Shenliang Yu, Lin Luan, Peter Choi, Shanta Nag, Pietro De Camilli, Kallol Gupta and Thomas J. Melia | Summary: Abstract During autophagosome biogenesis, the incorporation of transmembrane proteins into the expanding phagophore is not readily observed. In addition, the membrane surface area of the […]
Kavli Affiliate: Angeliki Louvi | Authors: Claudia dell’Amico, Marilyn Marlene Angulo Salavarria, Yutaka Takeo, Ichiko Saotome, Maria Teresa Dell’Anno, Maura Galimberti, Enrica Pellegrino, Elena Cattaneo, Angeliki Louvi and Marco Onorati | Summary: Abstract WDR62 is a spindle pole-associated scaffold protein with pleiotropic functions during corticogenesis. Recessive mutations in WDR62 are associated with structural brain abnormalities […]
Kavli Affiliate: John Carlson | Authors: Wanyue Wang, Hany K M Dweck, Gaëlle J.S. Talross, Ali Zaidi, Joshua M Gendron and John R Carlson | Summary: The agricultural pest Drosophila suzukii differs from most other Drosophila species in that it lays eggs in ripe, rather than overripe, fruit. Previously we showed that changes in bitter […]
Kavli Affiliate: Pietro DeCamilli | Authors: Daehun Park, Yumei Wu, Aaron Baublis and Pietro De Camilli | Summary: Ectopic expression in fibroblasts of synapsin 1 and synaptophysin is sufficient to generate condensates of vesicles highly reminiscent of synaptic vesicle (SV) clusters and with liquid-like properties. We show that unlike synaptophysin, other major integral SV membrane […]
Kavli Affiliate: Michael Crair | Authors: David O’Connor, Francesca Mandino, Xilin Shen, Corey Horien, Xinxin Ge, Peter Herman, Michael Crair, Xenophon Papademetris, Evelyn MR Lake and Robert Todd Constable | Summary: To improve bench-to-bedside translation, it is integral that knowledge flow bidirectionally from – animal models to humans, and vice versa. This will be facilitated […]