Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Variants in leucine rich repeat kinase 2 (LRRK2) that increase kinase activity confer risk for sporadic and familial forms of Parkinson’s disease. However, LRRK2-dependent cellular processes responsible for disease risk remain uncertain. Here we show that LRRK2 negatively regulates lysosome degradative […]

Kavli Affiliate: Nenad Sestan | Authors: Suel-Kee Kim, Seungmae Seo, Genevieve Stein-O’Brien, Amritha Jaishankar, Kazuya Ogawa, Nicola Micali, Victor Luria, Amir Karger, Yanhong Wang, Thomas M. Hyde, Joel E. Kleinman, Ty Voss, Elana J. Fertig, Joo-Heon Shin, Roland Bürli, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad […]

Kavli Affiliate: Michael Crair | Authors: Hadi Vafaii, Francesca Mandino, Gabriel Desrosiers-Gregoire, David O’Connor, Xilin Shen, Xinxin Ge, Peter Herman, Fahmeed Hyder, Xenophon Papademetris, Mallar Chakravarty, Michael Crair, Robert T Constable, Evelyn MR Lake and Luiz Pessoa | Summary: SUMMARY Understanding the organization of large-scale brain networks remains a central problem in neuroscience. Work in […]

Kavli Affiliate: Joerg Bewersdorf | Authors: Ons M’Saad, Michael Shribak and Joerg Bewersdorf | Summary: Abstract The spatial resolution and contrast sensitivity of the human eye is limited, restricting our ability to directly see subcellular structures. We report a new principle for unaided eye cellular visualization in a method we call Unclearing Microscopy. By expanding […]

Kavli Affiliate: Elena Gracheva | Authors: Luke H. Ziolkowski, Elena O. Gracheva and Sviatoslav N. Bagriantsev | Summary: Abstract Afferents of peripheral mechanoreceptors innervate the skin of vertebrates, where they detect physical touch via mechanically gated ion channels (mechanotransducers). While the afferent terminal is generally understood to be the primary site of mechanotransduction, the functional […]

Kavli Affiliate: Pasko Rakic, Nenad Sestan | Authors: Nicola Micali, Shaojie Ma, Mingfeng Li, Suel-Kee Kim, Xoel Mato-Blanco, Suvimal Sindhu, Jon I. Arellano, Tianliuyun Gao, Alvaro Duque, Gabriel Santpere, Nenad Sestan and Pasko Rakic | Summary: Abstract Early telencephalic development involves patterning of the distinct regions and fate specification of the neural stem cells (NSCs). […]

Kavli Affiliate: Pietro DeCamilli | Authors: Xinbo Wang, Javier Espadas, Yumei Wu, Shujun Cai, Jinghua Ge, Lin Shao, Aurélien Roux and Pietro De Camilli | Summary: Mutations in Leucine-rich repeat kinase 2 (LRRK2) are responsible for late-onset autosomal dominant Parkinson’s disease (PD). LRRK2 has been implicated in a wide range of physiological processes including membrane […]

Kavli Affiliate: Sreeganga Chandra | Authors: Eduardo Martin-Lopez, Charles A. GREER, Sreeganga Chandra, Vidyadhara D J, Teresa Liberia, Sarah J. Meller, Leah E. Harmon, Ryan M. Hsu, Kimberly Han and Betul Yucel | Summary: Abstract Parkinson’s Disease (PD) is characterized by multiple symptoms including olfactory dysfunction, whose underlying mechanisms remain unclear. Here, we explored pathological […]

Kavli Affiliate: Pietro DeCamilli | Authors: Taryn J. Olivas, Yumei Wu, Shenliang Yu, Lin Luan, Peter Choi, Shanta Nag, Pietro De Camilli, Kallol Gupta and Thomas J. Melia | Summary: Abstract During autophagosome biogenesis, the incorporation of transmembrane proteins into the expanding phagophore is not readily observed. In addition, the membrane surface area of the […]

Kavli Affiliate: Angeliki Louvi | Authors: Claudia dell’Amico, Marilyn Marlene Angulo Salavarria, Yutaka Takeo, Ichiko Saotome, Maria Teresa Dell’Anno, Maura Galimberti, Enrica Pellegrino, Elena Cattaneo, Angeliki Louvi and Marco Onorati | Summary: Abstract WDR62 is a spindle pole-associated scaffold protein with pleiotropic functions during corticogenesis. Recessive mutations in WDR62 are associated with structural brain abnormalities […]