Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology

Posted by klaurent Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E. Greene, Pietro De Camilli and Mian Cao | Summary: Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically enriched clathrin-uncoating factors, synaptojanin 1 […]


Continue.. Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology

Synergistic effect of mutations in the Parkinson’s disease-linked proteins synaptojanin 1 and auxilin

Posted by klaurent Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E. Greene, Pietro De Camilli and Mian Cao | Summary: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically-enriched clathrin-uncoating factors, synaptojanin 1 (SJ1) and […]


Continue.. Synergistic effect of mutations in the Parkinson’s disease-linked proteins synaptojanin 1 and auxilin

The incentive circuit: memory dynamics in the mushroom body of Drosophila melanogaster

Posted by klaurent Yale

Kavli Affiliate: Michael Nitabach | Authors: Evripidis Gkanias, Li Yan McCurdy, Michael N Nitabach and Barbara Webb | Summary: Insects adapt their response to stimuli, such as odours, according to their pairing with positive or negative reinforcements, such as sugar or shock. Recent electrophysiological and imaging findings in Drosophila melanogaster allow detailed examination of the […]


Continue.. The incentive circuit: memory dynamics in the mushroom body of Drosophila melanogaster

Canonical retinotopic shifts under an inverse force field explain predictive remapping

Posted by klaurent Yale

Kavli Affiliate: Michael Keiser | Authors: Laura M Gunsalus, Michael J. Keiser and Katherine S Pollard | Summary: ABSTRACT Predictive remapping — the ability of cells in retinotopic brain areas to transiently exhibit spatio-temporal retinotopic shifts beyond the spatial extent of their classical receptive fields — has been proposed as a primary mechanism that stabilizes […]


Continue.. Canonical retinotopic shifts under an inverse force field explain predictive remapping

Rapid fluctuations in functional connectivity of cortical networks encode spontaneous

Posted by klaurent Yale

Kavli Affiliate: Michael Crair, Jessica Cardin | Authors: Hadas Benisty, Daniel Barson, Andrew H. Moberly, Sweyta Lohani, Ronald R. Coifman, Gal Mishne, Michael C. Crair, Jessica A. Cardin and Michael J. Higley | Summary: Abstract Experimental work across a variety of species has demonstrated that spontaneously generated behaviors are robustly coupled to variation in neural […]


Continue.. Rapid fluctuations in functional connectivity of cortical networks encode spontaneous

Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior

Posted by klaurent Yale

Kavli Affiliate: Jessica Cardin & Michael Higley | Authors: Hadas Benisty, Andrew H Moberly, Sweyta Lohani, Daniel Barson, Ronald R Coifman, Gal Mishne, Jessica A Cardin and Michael J Higley | Summary: Abstract Experimental work across a variety of species has demonstrated that spontaneously generated behaviors are robustly coupled to variation in neural activity within […]


Continue.. Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior