Conserved neuropeptidergic regulation of intestinal integrity in invertebrate models of aging

Kavli Affiliate: Sreekanth Chalasani, Ethan Bier | Authors: Anupama Singh, Bhagyashree Kaduskar, Kirthi C Reddy, Caroline Kumsta, Ethan Bier, Malene Hansen and Sreekanth H Chalasani | Summary: Age-related decline in intestinal barrier function impacts survival across species, but the underlying cell intrinsic and extrinsic factors remain unclear. Here, we demonstrate a role for neuropeptides in […]


Continue.. Conserved neuropeptidergic regulation of intestinal integrity in invertebrate models of aging

Dynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Neuropsychiatric Disorders

Kavli Affiliate: Fred Gage, Terrence Sejnowski | Authors: Thodoros Bermperidis, Simon Schafer, Fred H. Gage, Terrence Sejnowski and Elizabeth B Torres | Summary: The advent of open access to genomic data offers new opportunities to revisit old clinical debates while approaching them from a different angle. We examine anew the question of whether psychiatric and […]


Continue.. Dynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Neuropsychiatric Disorders

Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall

Kavli Affiliate: Eric Halgren | Authors: Charles W Dickey, Ilya A Verzhbinsky, Xi Jiang, Burke Q Rosen, Sophie Kajfez, Brittany Stedelin, Jerry J Shih, Sharona Ben-Haim, Ahmed M Raslan, Emad N Eskandar, Jorge Gonzalez-Martinez, Sydney S Cash and Eric Halgren | Summary: Declarative memory encoding, consolidation, and retrieval require the integration of elements encoded in […]


Continue.. Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall

Reduced Dimension, Biophysical Neuron Models Constructed From Observed Data

Kavli Affiliate: Henry Abarbanel | Authors: Randall E Clark, Lawson Fuller, Jason A Platt and Henry Abarbanel | Summary: Using methods from nonlinear dynamics and interpolation techniques from applied mathematics, we show how to use data alone to construct discrete time dynamical rules that forecast observed neuron properties. These data may come from from simulations […]


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Long-term learning transforms prefrontal cortex representations during working memory

Kavli Affiliate: Anastasia Kiyonaga | Authors: Jacob Miller, Arielle Tambini, Anastasia Kiyonaga and Mark D’Esposito | Summary: The lateral prefrontal cortex (lPFC) is reliably active during working memory (WM) across human and animal models, but the role of lPFC in successful WM is under debate. For instance, non-human primate (NHP) electrophysiology research finds that lPFC […]


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Long-term ketogenic diet increases expression of SOX2-dependent oligodendrocyte- and myelination-associated genes in the aged mouse brain.

Kavli Affiliate: Jose Suarez Lopez | Authors: Matthew Stratton, Jose Alberto Lopez-Dominguez, Alessandro Canella, Jon J Ramsey and Gino A Cortopassi | Summary: Aging is associated with multiple neurodegenerative conditions that severely limit quality of life and shorten lifespan. Studies in rodents indicate that in addition to extending lifespan, the ketogenic diet improves cognitive function […]


Continue.. Long-term ketogenic diet increases expression of SOX2-dependent oligodendrocyte- and myelination-associated genes in the aged mouse brain.

Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission

Kavli Affiliate: David Kleinfeld | Authors: Abhi Aggarwal, Rui Liu, Yang Chen, Amelia J Ralowicz, Samuel J Bergerson, Filip Tomaska, Timothy L Hanson, Jeremy P Hasseman, Daniel Reep, Getahun Tsegaye, Pantong Yao, Xiang Ji, Marinus Kloos, Deepika Walpita, Ronak Patel, Paul W Tilberg, Boaz Mohar, The GENIE Project Team, Loren L Looger, Jonathan S Marvin, […]


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Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled

Kavli Affiliate: Samuel Pfaff | Authors: Remi Ronzano, Sophie Skarlatou, Bianca K Barriga, B. Anne Bannatyne, Gardave Singh Bhumbra, Joshua David Foster, Jeffrey Moore, Camille Lancelin, Amanda Pocratsky, Mustafa Gorkem Ozyurt, Calvin Chad Smith, Andrew J. Todd, David J. Maxwell, Andrew J. Murray, Samuel L Pfaff, Robert M. Brownstone, Niccolo’ Zampieri and Marco Beato | […]


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Fast rule switching and slow rule updating in a perceptual categorization task

Kavli Affiliate: Marcelo Mattar | Authors: Flora Bouchacourt, Sina Tafazoli, Marcelo Gomes Mattar, Timothy J Buschman and Nathaniel Douglass Daw | Summary: Abstract To adapt to a changing world, we must be able to switch between rules already learned and, at other times, learn rules anew. Often we must do both at the same time, […]


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Laminar Mechanisms of Saccadic Suppression in Primate Visual Cortex

Kavli Affiliate: John Reynolds | Authors: Sachira Denagamage, Mitchell P. Morton, John H. Reynolds, Monika P. Jadi and Anirvan S. Nandy | Summary: Saccades are a ubiquitous and crucial component of our visual system, allowing for the efficient deployment of the fovea and its accompanying neural resources. Initiation of a saccade is known to cause […]


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