FEMA: Fast and efficient mixed-effects algorithm for population-scale whole brain imaging data

Kavli Affiliate: Terry Jernigan, Anders Dale, Wesley Thompson | Authors: Chun Chieh Fan, Clare E Palmer, John Iverson, Diliana Pecheva, Oleksandr Frei, Dominic Holland, Wesley K Thompson, Donald Hagler, Terry L Jernigan, Ole Andreassen, Anders M. Dale and Thomas Nichols | Summary: The linear mixed effects model (LME) is a versatile modeling approach to deal […]


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MOSAIC: A Unified Trait Database to Complement Structured Population Models

Kavli Affiliate: Gabriel Silva | Authors: Connor Bernard, Gabriel Silva Santos, Jacques Deere, Roberto Rodriguez-Caro, Pol Capdevila, Erik Kusch, Samuel Gascoigne, John Jackson and Roberto Salguero-Gomez | Summary: The ecological sciences have joined the big data revolution. However, despite exponential growth in data availability, broader interoperability amongst datasets is still needed to unlock the potential […]


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Enzyme-Responsive Nanoparticles for the Targeted Delivery of an MMP Inhibitor to the Heart post Myocardial Infarction

Kavli Affiliate: Karen Christman | Authors: Holly Sullivan, Yifei Liang, Kendra Worthington, Colin Luo, Nathan C Gianneschi and Karen Christman | Summary: In this paper, we describe block copolymer amphiphiles consisting of a hydrophilic matrix metalloproteinase (MMP) peptide substrate, and a hydrophobic small molecule MMP inhibitor PD166793 for the treatment of acute myocardial infarction. These […]


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Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction

Kavli Affiliate: Anders Dale | Authors: Guy Hindley, Alexey A Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Borge Holen, Thomas Bjella, Chun Chieh Fan, Torill Uelan, Srdjan Djurovic, Olav B Smeland, Oleksandr Frei, Anders Dale and Ole Andreassen | Summary: Personality and cognition are […]


Continue.. Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction

Spatially distributed computation in cortical circuits

Kavli Affiliate: Thomas Albright | Authors: Sergei Gepshtein, Ambarish Pawar, Sunwoo Kwon, Sergey Savel’ev and Thomas D Albright | Summary: The traditional view of neural computation in the cerebral cortex holds that sensory neurons are specialized, i.e., selective for certain dimensions of sensory stimuli. This view was challenged by evidence of contextual interactions between stimulus […]


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The role of liver fat in cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

Kavli Affiliate: Anders Dale | Authors: Dennis van der Meer, Tiril P Gurholt, Ida E Sonderby, Alexey Shadrin, Guy FL Hindley, Zillur Rahman, Ann-Marie Glaso de Lange, Oleksandr Frei, Olof D Leinhard, Jennifer Linge, Rozalyn Simon, Lars T. Westlye, Sigrun Halvorsen, Anders Dale, Tom H Karlsen, Tobias Kaufmann and Ole A Andreassen | Summary: Background […]


Continue.. The role of liver fat in cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

Cortical ripples in humans

Kavli Affiliate: Eric Halgren | Authors:Charles W Dickey, Ilya A Verzhbinsky, Xi Jiang, Burke Q Rosen, Sophie Kajfez, Emad N Eskandar, Jorge Gonzalez-Martinez, Sydney S Cash and Eric Halgren | Summary: Hippocampal ripples index the reconstruction of spatiotemporal neuronal firing patterns essential for the consolidation of memories in the cortex during non-rapid eye movement sleep […]


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Conserved neuropeptidergic regulation of intestinal integrity in invertebrate models of aging

Kavli Affiliate: Sreekanth Chalasani, Ethan Bier | Authors: Anupama Singh, Bhagyashree Kaduskar, Kirthi C Reddy, Caroline Kumsta, Ethan Bier, Malene Hansen and Sreekanth H Chalasani | Summary: Age-related decline in intestinal barrier function impacts survival across species, but the underlying cell intrinsic and extrinsic factors remain unclear. Here, we demonstrate a role for neuropeptides in […]


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Dynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Neuropsychiatric Disorders

Kavli Affiliate: Fred Gage, Terrence Sejnowski | Authors: Thodoros Bermperidis, Simon Schafer, Fred H. Gage, Terrence Sejnowski and Elizabeth B Torres | Summary: The advent of open access to genomic data offers new opportunities to revisit old clinical debates while approaching them from a different angle. We examine anew the question of whether psychiatric and […]


Continue.. Dynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Neuropsychiatric Disorders

Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall

Kavli Affiliate: Eric Halgren | Authors: Charles W Dickey, Ilya A Verzhbinsky, Xi Jiang, Burke Q Rosen, Sophie Kajfez, Brittany Stedelin, Jerry J Shih, Sharona Ben-Haim, Ahmed M Raslan, Emad N Eskandar, Jorge Gonzalez-Martinez, Sydney S Cash and Eric Halgren | Summary: Declarative memory encoding, consolidation, and retrieval require the integration of elements encoded in […]


Continue.. Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall