Dysregulation of neuroproteasomes by ApoE isoforms drives endogenous Tau aggregation

Kavli Affiliate: V. S. Ramachandran | Authors: Victoria Paradise, Malavika Sabu, Joanna Bafia, Nyle A Sharif, Chi Nguyen, Rijuta Dhanraj Mukim, Kalin D Konrad-Vicario, Xiao Wang, Bianca T Corjuc, Jack Fu, Gabriella Maldonado, Jeffrey Ndubisi, Michael Strickland, Helen Figueroa, Douglas L Almeida, Bradley T Hyman, David M Holtzman, Tal Nuriel and Kapil V Ramachandran | […]


Continue.. Dysregulation of neuroproteasomes by ApoE isoforms drives endogenous Tau aggregation

Context-dependent sensory modulation underlies Bayesian vocal sequence perception

Kavli Affiliate: Ali Brivanlou, Eric Siggia | Authors: Anna Yoney, Lu Bai, Ali H. Brivanlou and Eric D Siggia | Summary: Vocal communication in both songbirds and humans relies on categorical perception of smoothly varying acoustic spaces. Vocal perception can be biased by expectation and context, but the mechanisms of this bias are not well […]


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Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

Kavli Affiliate: John Reynolds | Authors: Naici Guo, Giorgos Minas, Silvia A Synowsky, Margaret R Dunne, Hasnain Ahmed, Rhiannon McShane, Anshul Bhardwaj, Noel E Donlon, Cliona Lorton, Jacintha O’Sullivan, John V Reynolds, Peter D Caie, Sally L Shirran, Andy G Lynch, Alan Stewart and Swati Arya | Summary: Oesophageal adenocarcinoma (OAC) is an aggressive cancer […]


Continue.. Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

Active vision during prey-capture in wild marmoset monkeys

Kavli Affiliate: Cory Miller | Authors: Victoria Ngo, Cory Miller, Julia Gorman, Maria Fernanda De La Fuente, Antonio Souto and Nicola Schiel | Summary: Here, we examined prey-capture in wild common marmosets (Callithrix jacchus) to explicate the active role of primate vision for high-precision, goal-directed motor actions in challenging natural environments. We observed distinct marmoset […]


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Sensory readout accounts for adaptation

Kavli Affiliate: John Serences | Authors: Timothy C. Sheehan and John T. Serences | Summary: Sensory responses and behavior are strongly shaped by stimulus history. For instance, perceptual reports are sometimes biased towards previously viewed stimuli (serial dependence). While behavioral studies have pointed to both perceptual and post-perceptual origins of this phenomenon, neural data that […]


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Two modes of mid-frontal theta suggest a role in conflict and error processing

Kavli Affiliate: Adam Aron | Authors: Vignesh Muralidharan, Adam R Aron, Micheal X Cohen and Robert Schmidt | Summary: Mid-frontal theta is well-known to be involved in conflict and error-processing. In paradigms known to evoke response conflict, the temporal sequence of events leading up to conflict or error resolution and theta’s involvement in such scenarios […]


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CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons

Kavli Affiliate: William Mobley | Authors: Gong-Her Wu, Charlene Smith-Geater, Jesus G. Galaz-Montoya, Yingli Gu, Sanket R Gupte, Ranen Aviner, Patrick G. Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette Geller, Cristina Danita, Lydia-Marie Joubert, Michael F. Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M. Thompson and Wah Chiu | Summary: […]


Continue.. CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons

Interplay between rule learning and rule switching in a perceptual categorization task

Kavli Affiliate: Marcelo Mattar | Authors: Flora Bouchacourt, Sina Tafazoli, Marcelo Gomes Mattar, Timothy J Buschman and Nathaniel Douglass Daw | Summary: To adapt to a changing world, we must be able to switch between rules already learned and, at other times, learn rules anew. Often we must do both at the same time, switching […]


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Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

Kavli Affiliate: Terry Jernigan | Authors: Amirhossein Modabbernia, Didac Vidal-Pineiro, Ingrid Agartz, Ole A Andreassen, Rosa Ayesa-Arriola, Alessandro Bertolino, Dorret I Boomsma, Josiane Bourque, Alan Breier, Rachel M Brouwer, Jan K Buitelaar, Erick J Canales-Rodriguez, Xavier Caseras, Patricia J Conrod, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A Crone, Greig I de Zubicaray, Erin W Dickie, Danai […]


Continue.. Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets

Kavli Affiliate: Angela Wu | Authors: Jia Zhao, Gefei Wang, Jingsi Ming, Zhixiang Lin, Yang Wang, The Tabula Microcebus Consortium, Angela Ruohao Wu and Can Yang | Summary: The rapid emergence of large-scale atlas-level single-cell RNA-seq datasets presents remarkable opportunities for broad and deep biological investigations through integrative analyses. However, harmonizing such datasets requires integration […]


Continue.. Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets