Kavli Affiliate: Jyoti Mishra | Authors: Sandeep Sathyanandan Nair, Vignayanandam Ravindernath Muddapu, Vigneswaran C, Pragathi Priyadharsini Balasubramani, Jyoti Mishra, Dhaskshin S Ramanathan and V Srinivasa Chakravarthy | Summary: Human cognition is characterized by a wide range of capabilities including goal-oriented selective attention, distractor suppression, decision making, response inhibition, and working memory. Much research has focused […]

Kavli Affiliate: Nicholas Spitzer | Authors: Marta Pratelli, Arth Thaker, Huiquan Li, Swetha Godavarthi and Nicholas C. Spitzer | Summary: Decreased cognitive ability is a major consequence of exposure to drugs of abuse, but the underlying neuroplastic changes have been elusive. We show that both phencyclidine and methamphetamine cause a population of prelimbic pyramidal neurons […]

Kavli Affiliate: Fred Gage | Authors: Madison Wilson, Martin Thunemann, Xin Liu, Yichen Lu, Francesca Puppo, Jason Adams, Jeong-Hoon Kim, Donald Pizzo, Srdjan Djurovic, Ole Andreassen, Abed Mansour, Fred H. Gage, Alysson R Muotri, Anna Devor and Duygu Kuzum | Summary: Human cortical organoids, three-dimensional neuronal cell cultures derived from human induced pluripotent stem cells, […]

Kavli Affiliate: V. S. Ramachandran | Authors: Vignesh Ramachandran, Gregory Hatlestad and Travis White | Summary: Background: One way single-celled eukaryotes respond to DNA damage stress is by modifying their gene expression, facilitating genomic repair. Gene expression responses to DNA damage induced by methyl methanesulfonate (MMS) have been studied in the model organism Saccharomyces cerevisiae. […]

Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Hasti Atashi and Solomon Snyder | Summary: The hippocampal CA3 subregion is a densely connected recurrent circuit that supports memory consolidation and retrieval by generating and storing sequential neuronal activity patterns that reflect recent experience. The encoding of precise temporal firing patterns in CA3 ensembles during awake-behavior […]

Kavli Affiliate: John Reynolds | Authors: Courtney Glavis-Bloom, Casey R Vanderlip and John H Reynolds | Summary: Aging is the greatest risk factor for the development of neurodegenerative diseases, yet we still do not understand how the aging process leads to pathological vulnerability. The research community has relied heavily on mouse models, but the considerable […]

Kavli Affiliate: Jose Suarez Lopez | Authors: Ines Marin, Olga Boix, Andrea Garcia-Garijo, isabelle Sirois, Adria Caballe, Eduardo Zarzuela, Irene Ruano, Camille Stephan-Otto Attolini, Neus Prats, Jose Alberto Lopez-Dominguez, Marta Kovatcheva, Elena Garralda, Javier Munoz, Etienne Caron, Maria Abad, Alena Gros, Federico Pietrocola and Manuel Serrano | Summary: Cellular senescence is a stress response that […]

Kavli Affiliate: Jean Pierre Changeux | Authors: Sophie Shi, Solene N Lefebvre, Laurie Peverini, Adrien H Cerdan, Marc Gielen, Jean-Pierre Changeux, Marco CECCHINI and Pierre-Jean Corringer | Summary: Pentameric ligand-gated ion channel mediate signal transduction at chemical synapses by transiting between resting and open states upon neurotransmitter binding. Here, we investigate the gating transition of […]

Kavli Affiliate: Wesley Thompson | Authors: James Talwar, David Laub, Meghana Pagadala, Andrea Castro, McKenna Lewis, Georg E. Luebeck, Bryan Gorman, Cuiping Pan, Frederick N. Dong, Kyriacos Markianos, Richard Hauger, Saiju Pyarajan, Philip S. Tsao, Gerald P. Morris, Rany M. Salem, Wesley K. Thompson, Kit Curtius, Maurizio Zanetti and Hannah Carter | Summary: Autoimmunity and […]

Kavli Affiliate: Terrence Sejnowski | Authors: Yusi Chen, Huanqiu Zhang and Terrence J Sejnowski | Summary: The interaction between hippocampus and cortex is key to memory formation and representation learning. Based on anatomical wiring and transmission delays, we proposed a self-supervised recurrent neural network (PredRAE) with a predictive reconstruction loss to account for the cognitive […]