Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Kavli Affiliate: Jean Pierre Changeux | Authors: Sophie Shi, Solene N Lefebvre, Laurie Peverini, Adrien H Cerdan, Marc Gielen, Jean-Pierre Changeux, Marco CECCHINI and Pierre-Jean Corringer | Summary: Pentameric ligand-gated ion channel mediate signal transduction at chemical synapses by transiting between resting and open states upon neurotransmitter binding. Here, we investigate the gating transition of […]


Continue.. Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility

Kavli Affiliate: Wesley Thompson | Authors: James Talwar, David Laub, Meghana Pagadala, Andrea Castro, McKenna Lewis, Georg E. Luebeck, Bryan Gorman, Cuiping Pan, Frederick N. Dong, Kyriacos Markianos, Richard Hauger, Saiju Pyarajan, Philip S. Tsao, Gerald P. Morris, Rany M. Salem, Wesley K. Thompson, Kit Curtius, Maurizio Zanetti and Hannah Carter | Summary: Autoimmunity and […]


Continue.. Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility

Hippocampus as a generative circuit for predictive coding of future sequences

Kavli Affiliate: Terrence Sejnowski | Authors: Yusi Chen, Huanqiu Zhang and Terrence J Sejnowski | Summary: The interaction between hippocampus and cortex is key to memory formation and representation learning. Based on anatomical wiring and transmission delays, we proposed a self-supervised recurrent neural network (PredRAE) with a predictive reconstruction loss to account for the cognitive […]


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Interactive Neurorobotics: Behavioral and Neural Dynamics of Agent Interactions

Kavli Affiliate: Andrea Chiba | Authors: Eric J Leonardis, Leo Breston, Rhiannon Lucero-Moore, Leigh Sena, Raunit Kohli, Luisa Schuster, Lacha Barton-Gluzman, Laleh K Quinn, Janet Wiles and Andrea Chiba | Summary: Interactive neurorobotics is a subfield which characterizes brain responses evoked during interaction with a robot, and their relationship with the behavioral responses. Gathering rich […]


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Immunomodulatory Extracellular Matrix Hydrogel Mitigates Scar Formation in a Model of Tongue Fibrosis.

Kavli Affiliate: Karen Christman | Authors: mma I Zelus, Aaron Panduro, Marianna Alperin, Andrew M Vahabzadeh-Hagh and Karen L Christman | Summary: Background: While head and neck cancer treatment regimens, including surgical resection, irradiation, and chemotherapy, are effective at removing tumors, they lead to muscle atrophy, denervation, and fibrosis, contributing to the pathogenesis of tongue […]


Continue.. Immunomodulatory Extracellular Matrix Hydrogel Mitigates Scar Formation in a Model of Tongue Fibrosis.

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

Kavli Affiliate: Wesley Thompson | Authors: Meghana Pagadala, Victoria H. Wu, Eva Perez-Guijarro, Hyo Kim, Andrea Castro, James Talwar, Timothy Sears, Cristian Gonzalez-Colin, Steven Cao, Benjamin Schmiedel, Shervin Goudarzi, Divya Kirani, Rany Salem, Gerald Morris, Olivier Harismendy, Sandip Pravin Patel, Jill P. Mesirov, Maurizio Zanetti, Chi-Ping Day, Chun Chieh Fan, Wesley K. Thompson, Glenn Merlino, […]


Continue.. Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

Kavli Affiliate: Fred Gage | Authors: Shani Stern, Lei Zhang, Meiyan Wang, Rebecca Wright, Diogo Cordeiro, David Peles, Yuqing Hang, Ana P Mendes, Tithi Baul, Julien Roth, Shashank Coorapati, Marco Boks, Hilleke Hulshoff Pol, Kristen J. Brennand, Janos M Rethelyi, Rene S. Kahn, Maria C. Marchetto and Fred H. Gage | Summary: Schizophrenia affects approximately […]


Continue.. Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

BigNeuron: A resource to benchmark and predict best-performing algorithms for automated reconstruction of neuronal morphology

Kavli Affiliate: Ann Shyn Chiang, Kristofer Bouchard | Authors: Linus Manubens-Gil, Zhi Zhou, Hanbo Chen, Arvind Ramanathan, Xiaoxiao Liu, Yufeng Liu, Alessandro Bria, Todd Gillette, Zongcai Ruan, Jian Yang, Miroslav Radojević, Ting Zhao, Li Cheng, Lei Qu, Siqi Liu, Kristofer E. Bouchard, Lin Gu, Weidong Cai, Shuiwang Ji, Badrinath Roysam, Ching-Wei Wang, Hongchuan Yu, Amos […]


Continue.. BigNeuron: A resource to benchmark and predict best-performing algorithms for automated reconstruction of neuronal morphology

Repeated birth injuries lead to pelvic floor muscle dysfunction and impairment in regeneration

Kavli Affiliate: Karen Christman | Authors: Pamela Duran, Emma Zelus, Saya French, Lindsey Burnett, Karen Christman and Marianna Alperin | Summary: Objectives: Childbirth is a key risk factor for pelvic floor muscle (PFM) injury and dysfunction, and subsequent pelvic floor disorders (PFDs). Multiparity further exacerbates these risks. Using the pre-clinical rat model of simulated birth […]


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High precision magnetoencephalography reveals increased right-inferior frontal gyrus beta power during response conflict

Kavli Affiliate: Adam Aron | Authors: Pria L Daniel, James J Bonaiuto, Sven Bestmann, Adam R Aron and Simon Little | Summary: Flexibility of behavior and the ability to rapidly switch actions is critical for adaptive living in humans. It is well established that the right-inferior frontal gyrus (R-IFG) is recruited during outright action-stopping, relating […]


Continue.. High precision magnetoencephalography reveals increased right-inferior frontal gyrus beta power during response conflict