Protein Geometry, Function and Mutation

Kavli Affiliate: Robert Clark | Authors: Robert Clark Penner | Summary: Abstract This survey summarizes several works by the author on protein geometry and protein function with applications to viral glycoproteins in general and the spike glycoprotein of the SARS-CoV-2 virus in particular. Though a certain level of mathematical sophistication is assumed, the background biology […]


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Mouse lemur transcriptomic atlas elucidates primate genes, physiology, disease, and evolution

Kavli Affiliate: Angela Wu | Authors: The Tabula Microcebus Consortium, Camille Ezran, Shixuan Liu, Jingsi Ming, Lisbeth A. Guethlein, Michael F. Z. Wang, Roozbeh Dehghannasiri, Julia Olivieri, Hannah K. Frank, Alexander Tarashansky, Winston Koh, Qiuyu Jing, Olga Botvinnik, Jane Antony, Stephen Chang, Angela Oliveira Pisco, Jim Karkanias, Can Yang, James E. Ferrell, Jr., Scott D. […]


Continue.. Mouse lemur transcriptomic atlas elucidates primate genes, physiology, disease, and evolution

Thalamus sends information about arousal but not valence to the amygdala

Kavli Affiliate: Kay Tye | Authors: Chris A Leppla, Laurel Keyes, Gordon Glober, Gillian A Matthews, Kanha Batra, Maya Jay, Yu Feng, Hannah S Chen, Fergil Mills, Jeremy Delahanty, Jake Olsen, Edward H Nieh, Praneeth Namburi, Craig Wildes, Romy Wichmann, Anna Beyelar, Eyal Y Kimchi and Kay M. Tye | Summary: Rationale The basolateral amygdala […]


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Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys

Kavli Affiliate: John Reynolds, Kenneth Miller | Authors: Alessandro Sanzeni, Agostina Palmigiano, Tuan H Nguyen, Junxiang Luo, Jonathan J Nassi, John H Reynolds, Mark H Histed, Kenneth D Miller and Nicolas Brunel | Summary: The ability to observe the response of neural circuits to controlled optogenetic perturbations opens an unprecedented window into the mechanisms governing […]


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Rewiring Dynamics of Functional Connectome in Motor Cortex during Motor Skill Learning

Kavli Affiliate: Takaki Komiyama | Authors: Saber Meamardoost, Eunjung Hwang, Mahasweta Bhattacharya, Chi Ren, Linbing Wang, Claudia Mewes, Ying Zhang, Takaki Komiyama and Rudiyanto Gunawan | Summary: The brain’s connectome continually rewires throughout the life of an organism. In this study, we sought to elucidate the operational principles of such rewiring by analyzing the functional […]


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The spatial distribution and temporal trends of livestock damages caused by wolves in Europe

Kavli Affiliate: Jose Suarez Lopez | Authors: Liam Singer, Xenia Wietlisbach, Raffael Hickisch, Eva Maria Schoell, Angela Van den Broek, Manon Désalme, Koen Driesen, Mari Lyly, Francesca Marucco, Miroslav Kutal, Nives Pagon, Cristian Remus Papp, Paraskevi Milioni, Remigijus Uzdras, Ilgvars Zihmanis, Fridolin Zimmermann, Katrina Marsden, Klaus Hackländer, José Vicente López-Bao, Sybille Klenzendorf and Daniel Wegmann […]


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Large-scale capture of hidden fluorescent labels for training generalizable markerless motion capture models

Kavli Affiliate: Eiman Azim | Authors: Daniel J Butler, Alexander P Keim, Shantanu Ray and Eiman Azim | Summary: Recent advances in deep learning-based markerless pose estimation have dramatically improved the scale and ease with which body landmarks can be tracked in studies of animal behavior. However, pose estimation for animals in a laboratory setting […]


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Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

Kavli Affiliate: Gabriel Silva | Authors: Bruna M. Silva, Flavio Protasio Veras, Giovanni Gomes, Seppe Cambier, Gabriel Silva, Andreza Quadros, Diego Caetite, Daniele Nascimento, Camila Silva, Juliana Silva, Samara Damasceno, Ayda Schneider, Fabio Beretta, Sabrina Batah, Icaro Castro, Isadora Paiva, Tamara Rodrigues, Ana C G Salina, Ronaldo Martins, Guilherme Cebinelli, Naira Bibo, Daniel Jorge, Helder […]


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Global worming: massive invasion of North America by earthworms revealed

Kavli Affiliate: John Reynolds | Authors: Jerome Mathieu, John Warren Reynolds, Carlos Fragoso and Elizabeth Hadly | Summary: Human activities cause major ecological changes by reshuffling the spatial distribution of species. The extent to which this process affects belowground biota is a critical issue because soil organisms play a key role in ecosystem functioning and […]


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Cortical ripples during NREM sleep and waking in humans

Kavli Affiliate: Eric Halgren | Authors: Charles W Dickey, Ilya A Verzhbinsky, Xi Jiang, Burke Q Rosen, Sophie Kajfez, Emad N Eskandar, Jorge Gonzalez-Martinez, Sydney S Cash and Eric Halgren | Summary: Hippocampal ripples index the reconstruction of spatiotemporal neuronal firing patterns essential for the consolidation of memories in the cortex during non-rapid eye movement […]


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