Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

Kavli Affiliate: Gabriel Silva | Authors: Bruna M. Silva, Flavio Protasio Veras, Giovanni Gomes, Seppe Cambier, Gabriel Silva, Andreza Quadros, Diego Caetite, Daniele Nascimento, Camila Silva, Juliana Silva, Samara Damasceno, Ayda Schneider, Fabio Beretta, Sabrina Batah, Icaro Castro, Isadora Paiva, Tamara Rodrigues, Ana C G Salina, Ronaldo Martins, Guilherme Cebinelli, Naira Bibo, Daniel Jorge, Helder […]


Continue.. Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

Global worming: massive invasion of North America by earthworms revealed

Kavli Affiliate: John Reynolds | Authors: Jerome Mathieu, John Warren Reynolds, Carlos Fragoso and Elizabeth Hadly | Summary: Human activities cause major ecological changes by reshuffling the spatial distribution of species. The extent to which this process affects belowground biota is a critical issue because soil organisms play a key role in ecosystem functioning and […]


Continue.. Global worming: massive invasion of North America by earthworms revealed

Cortical ripples during NREM sleep and waking in humans

Kavli Affiliate: Eric Halgren | Authors: Charles W Dickey, Ilya A Verzhbinsky, Xi Jiang, Burke Q Rosen, Sophie Kajfez, Emad N Eskandar, Jorge Gonzalez-Martinez, Sydney S Cash and Eric Halgren | Summary: Hippocampal ripples index the reconstruction of spatiotemporal neuronal firing patterns essential for the consolidation of memories in the cortex during non-rapid eye movement […]


Continue.. Cortical ripples during NREM sleep and waking in humans

A Generalized Reinforcement Learning-Based Deep Neural Network (GRL-DNN) Agent Model for Diverse Cognitive Constructs

Kavli Affiliate: Jyoti Mishra | Authors: Sandeep Sathyanandan Nair, Vignayanandam Ravindernath Muddapu, Vigneswaran C, Pragathi Priyadharsini Balasubramani, Jyoti Mishra, Dhaskshin S Ramanathan and V Srinivasa Chakravarthy | Summary: Human cognition is characterized by a wide range of capabilities including goal-oriented selective attention, distractor suppression, decision making, response inhibition, and working memory. Much research has focused […]


Continue.. A Generalized Reinforcement Learning-Based Deep Neural Network (GRL-DNN) Agent Model for Diverse Cognitive Constructs

Phencyclidine and methamphetamine cause cognitive deficits by changing pyramidal neuron transmitter identity in the prefrontal cortex

Kavli Affiliate: Nicholas Spitzer | Authors: Marta Pratelli, Arth Thaker, Huiquan Li, Swetha Godavarthi and Nicholas C. Spitzer | Summary: Decreased cognitive ability is a major consequence of exposure to drugs of abuse, but the underlying neuroplastic changes have been elusive. We show that both phencyclidine and methamphetamine cause a population of prelimbic pyramidal neurons […]


Continue.. Phencyclidine and methamphetamine cause cognitive deficits by changing pyramidal neuron transmitter identity in the prefrontal cortex

Multimodal monitoring of human cortical organoids implanted in mice using transparent graphene microelectrodes reveal functional connection between organoid and mouse visual cortex

Kavli Affiliate: Fred Gage | Authors: Madison Wilson, Martin Thunemann, Xin Liu, Yichen Lu, Francesca Puppo, Jason Adams, Jeong-Hoon Kim, Donald Pizzo, Srdjan Djurovic, Ole Andreassen, Abed Mansour, Fred H. Gage, Alysson R Muotri, Anna Devor and Duygu Kuzum | Summary: Human cortical organoids, three-dimensional neuronal cell cultures derived from human induced pluripotent stem cells, […]


Continue.. Multimodal monitoring of human cortical organoids implanted in mice using transparent graphene microelectrodes reveal functional connection between organoid and mouse visual cortex

Genomic expression responses in sensu stricto Saccharomyces yeast to DNA damage induced by methyl methanesulfonate

Kavli Affiliate: V. S. Ramachandran | Authors: Vignesh Ramachandran, Gregory Hatlestad and Travis White | Summary: Background: One way single-celled eukaryotes respond to DNA damage stress is by modifying their gene expression, facilitating genomic repair. Gene expression responses to DNA damage induced by methyl methanesulfonate (MMS) have been studied in the model organism Saccharomyces cerevisiae. […]


Continue.. Genomic expression responses in sensu stricto Saccharomyces yeast to DNA damage induced by methyl methanesulfonate

Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in hippocampal CA3 place cells

Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Hasti Atashi and Solomon Snyder | Summary: The hippocampal CA3 subregion is a densely connected recurrent circuit that supports memory consolidation and retrieval by generating and storing sequential neuronal activity patterns that reflect recent experience. The encoding of precise temporal firing patterns in CA3 ensembles during awake-behavior […]


Continue.. Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in hippocampal CA3 place cells

Age-related learning and working memory impairment in the common marmoset

Kavli Affiliate: John Reynolds | Authors: Courtney Glavis-Bloom, Casey R Vanderlip and John H Reynolds | Summary: Aging is the greatest risk factor for the development of neurodegenerative diseases, yet we still do not understand how the aging process leads to pathological vulnerability. The research community has relied heavily on mouse models, but the considerable […]


Continue.. Age-related learning and working memory impairment in the common marmoset

Induction of senescence renders cancer cells highly immunogenic

Kavli Affiliate: Jose Suarez Lopez | Authors: Ines Marin, Olga Boix, Andrea Garcia-Garijo, isabelle Sirois, Adria Caballe, Eduardo Zarzuela, Irene Ruano, Camille Stephan-Otto Attolini, Neus Prats, Jose Alberto Lopez-Dominguez, Marta Kovatcheva, Elena Garralda, Javier Munoz, Etienne Caron, Maria Abad, Alena Gros, Federico Pietrocola and Manuel Serrano | Summary: Cellular senescence is a stress response that […]


Continue.. Induction of senescence renders cancer cells highly immunogenic