Encoding of Dynamic Facial Information in the Middle Dorsal Face Area

Kavli Affiliate: Winrich Freiwald | Authors: Zetian Yang and Winrich A. Freiwald | Summary: Abstract Faces in motion reveal a plethora of information through visual dynamics. Faces can move in complex patterns while transforming facial shape, e.g. during the generation of different emotional expressions. While motion and shape processing have been studied extensively in separate […]


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The energetics of rapid cellular mechanotransduction

Kavli Affiliate: Michael Young | Authors: Michael N Young, Michael J Sindoni, Amanda H Lewis, Stefan Zauscher and Jorg Grandl | Summary: Cells throughout the human body detect mechanical forces. While it is known that the rapid (millisecond) detection of mechanical forces is mediated by force-gated ion channels, a detailed quantitative understanding of cells as […]


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A Draft Human Pangenome Reference

Kavli Affiliate: Erich Jarvis | Authors: Wen-Wei Liao, Mobin Asri, Jana Ebler, Daniel Doerr, Marina Haukness, Glenn Hickey, Shuangjia Lu, Julian K. Lucas, Jean Monlong, Haley J. Abel, Silvia Buonaiuto, Xian H. Chang, Haoyu Cheng, Justin Chu, Vincenza Colonna, Jordan M. Eizenga, Xiaowen Feng, Christian Fischer, Robert S. Fulton, Shilpa Garg, Cristian Groza, Andrea Guarracino, […]


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Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

Kavli Affiliate: Jean Laurent Casanova | Authors: Gaspard Kerner, Anna-Lena Neehus, Laurent Abel, Jean-Laurent Casanova, Etienne Patin, Guillaume Laval and Lluis Quintana-Murci | Summary: Ancient genomics can directly detect human genetic adaptation to environmental cues. However, it remains unclear how pathogens have exerted selective pressures on human genome diversity across different epochs and affected present-day […]


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Convergent gene expression highlights shared vocal motor microcircuitry in songbirds and humans

Kavli Affiliate: Erich Jarvis | Authors: Gregory L Gedman, Matthew T Biegler, Bettina Haase, Morgan Wirthlin, Olivier Fedrigo, Andreas R Pfenning and Erich D Jarvis | Summary: Vocal learning is a skilled motor behavior observed in several mammalian and avian species and is critical for human speech. While convergent gene expression patterns have highlighted similar […]


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Quantitative prediction and measurement of Piezo’s membrane footprint

Kavli Affiliate: Roderick MacKinnon | Authors: Christoph A. Haselwandter, Roderick MacKinnon, Yusong Guo and Ziao Fu | Summary: Piezo proteins are mechanosensitive ion channels that can locally curve the membrane into a dome shape (Y. R. Guo, R. MacKinnon, 2017). The curved shape of the Piezo dome is expected to deform the surrounding lipid bilayer […]


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Differential sensory and immune gene evolution in sea turtles with contrasting demographic and life histories

Kavli Affiliate: Erich Jarvis | Authors: Blair P Bentley, Tomás Carrasco-Valenzuela, Elisa K. S. Ramos, Harvinder Pawar, Larissa Souza Arantes, Alana Alexander, Shreya M Banerjee, Patrick Masterson, Martin Kuhlwilm, Martin Pippel, Jacquelyn Mountcastle, Bettina Haase, Marcela Uliano Silva, Giulio Formenti, Kerstin Howe, William Chow, Alan Tracey, Yumi Sims, Sarah Pelan, Jonathan Wood, Kelsey Yetsko, Justin […]


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All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals

Kavli Affiliate: Cori Bargmann | Authors: Amelie CF Bergs, Jana F Liewald, Silvia Rodriguez-Rozada, Qiang Liu, Christin Wirt, Artur Bessel, Nadja Zeitzschel, Hilal Durmaz, Adrianna Nozownik, Johannes Vierock, Cori Bargmann, Peter Hegemann, J. Simon Wiegert and Alexander Gottschalk | Summary: Optogenetics are used to stimulate or inhibit neurons. Because optogenetic stimulation is typically static, neurons […]


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A developmental pathway for epithelial-to-motoneuron transformation in C. elegans

Kavli Affiliate: Shai Shaham | Authors: Alina Rashid, Maya Tevlin, Yun Lu and Shai Shaham | Summary: Motoneurons and motoneuron-like pancreatic beta cells arise from radial glia and ductal cells, both tube-lining progenitors that share molecular regulators. To uncover programs underlying motoneuron formation, we studied a similar, cell-division-independent transformation of the C. elegans tube-lining Y […]


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The swan genome and transcriptome: its not all black and white

Kavli Affiliate: Erich Jarvis | Authors: Anjana C. Karawita, Yuanyuan Cheng, Keng Yih Chew, Arjun Challgula, Robert Kraus, Ralf C. Mueller, Marcus Z. W. Tong, Katina D. Hulme, Helle Beielefeldt-Ohmann, Lauren E. Steele, Melanie Wu, Julian DJ Sng, Ellesandra Noye, Timothy J. Bruxner, Gough G. Au, Suzanne Lowthe, Julie Blommaert, Alexander Suh, Alexander J. McCauley, […]


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