Kavli Affiliate: Roderick MacKinnon | Authors: Christoph A. Haselwandter, Roderick MacKinnon, Yusong Guo and Ziao Fu | Summary: Piezo proteins are mechanosensitive ion channels that can locally curve the membrane into a dome shape (Y. R. Guo, R. MacKinnon, 2017). The curved shape of the Piezo dome is expected to deform the surrounding lipid bilayer […]
Kavli Affiliate: Erich Jarvis | Authors: Blair P Bentley, Tomás Carrasco-Valenzuela, Elisa K. S. Ramos, Harvinder Pawar, Larissa Souza Arantes, Alana Alexander, Shreya M Banerjee, Patrick Masterson, Martin Kuhlwilm, Martin Pippel, Jacquelyn Mountcastle, Bettina Haase, Marcela Uliano Silva, Giulio Formenti, Kerstin Howe, William Chow, Alan Tracey, Yumi Sims, Sarah Pelan, Jonathan Wood, Kelsey Yetsko, Justin […]
Kavli Affiliate: Cori Bargmann | Authors: Amelie CF Bergs, Jana F Liewald, Silvia Rodriguez-Rozada, Qiang Liu, Christin Wirt, Artur Bessel, Nadja Zeitzschel, Hilal Durmaz, Adrianna Nozownik, Johannes Vierock, Cori Bargmann, Peter Hegemann, J. Simon Wiegert and Alexander Gottschalk | Summary: Optogenetics are used to stimulate or inhibit neurons. Because optogenetic stimulation is typically static, neurons […]
Kavli Affiliate: Shai Shaham | Authors: Alina Rashid, Maya Tevlin, Yun Lu and Shai Shaham | Summary: Motoneurons and motoneuron-like pancreatic beta cells arise from radial glia and ductal cells, both tube-lining progenitors that share molecular regulators. To uncover programs underlying motoneuron formation, we studied a similar, cell-division-independent transformation of the C. elegans tube-lining Y […]
Kavli Affiliate: Erich Jarvis | Authors: Anjana C. Karawita, Yuanyuan Cheng, Keng Yih Chew, Arjun Challgula, Robert Kraus, Ralf C. Mueller, Marcus Z. W. Tong, Katina D. Hulme, Helle Beielefeldt-Ohmann, Lauren E. Steele, Melanie Wu, Julian DJ Sng, Ellesandra Noye, Timothy J. Bruxner, Gough G. Au, Suzanne Lowthe, Julie Blommaert, Alexander Suh, Alexander J. McCauley, […]
Kavli Affiliate: Winrich Freiwald | Authors: Ben Deen and Winrich A Freiwald | Summary: What is the cognitive and neural architecture for high-level reasoning? We hypothesize that systems for understanding people and places remain separate throughout the brain, but share a parallel organization. We test this hypothesis using deep neuroimaging of individual human brains on […]
Kavli Affiliate: Jean Laurent Casanova | Authors: Peng Zhang, Quentin Philippot, Weicheng Ren, Wei-Te Lei, Juan Li, Peter D. Stenson, Pere Soler Palacín, Roger Colobran, Bertrand Boisson, Shen-Ying Zhang, Anne Puel, Qiang Pan-Hammarström, Qian Zhang, David N. Cooper, Laurent Abel and Jean-Laurent Casanova | Summary: Pre-mRNA splicing is initiated with the recognition of a single-nucleotide […]
Kavli Affiliate: Cori Bargmann | Authors: Javier Marquina-Solis, Elke Vandewyver, Josh Hawk, Daniel Colon-Ramos, Isabel Beets and Cori Bargmann | Summary: Pathogenic infection elicits sickness behaviors that promote recovery and survival of the host. For example, following infection with the pathogenic bacterium Pseudomonas aeruginosa PA14, the nematode Caenorhabditis elegans modifies its sensory preferences to avoid […]
Kavli Affiliate: Ali Brivanlou, Eric Siggia | Authors: Anna Yoney, Lu Bai, Ali H. Brivanlou and Eric D Siggia | Summary: Embryogenesis is guided by a limited set of signaling pathways dynamically expressed in different places. How a context dependent signaling response is generated has been a central question of developmental biology, which can now […]
Kavli Affiliate: Li Zhao | Authors: Eric B Zheng and Li Zhao | Summary: De novo gene origination, where a previously non-genic genomic sequence becomes genic through evolution, has been increasingly recognized as an important source of evolutionary novelty across diverse taxa. Many de novo genes have been proposed to be protein-coding, and in several […]