FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons

Kavli Affiliate: Jeffrey Friedman | Authors: Mihwa Choi, Marc Schneeberger, Wei Fan, Abhijit Bugde, Laurent Gautron, Kevin Vale, Yuan Zhang, Jeffrey M. Friedman, David J. Mangelsdorf and Steven A. Kliewer | Summary: SUMMARY Animals that consume fermenting fruit or nectar are exposed to ethanol, thus increasing their risk of injury or predation. This risk is […]


Continue.. FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons

Piezo1 as a force-through-membrane sensor in red blood cells.

Kavli Affiliate: Roderick MacKinnon | Authors: George Vaisey, Priyam Banerjee, Alison J North, Christoph A Haselwandter and Roderick MacKinnon | Summary: Summary Piezo1 is the stretch activated Ca2+ channel in red blood cells that mediates homeostatic volume control. Here we study the organization of Piezo1 in red blood cells using a combination of super resolution […]


Continue.. Piezo1 as a force-through-membrane sensor in red blood cells.

Sex differences in inter-individual gene expression variability across human tissues

Kavli Affiliate: Li Zhao | Authors: Samuel Khodursky, Caroline S Jiang, Eric B Zheng, Roger Vaughan, Daniel R Schrider and Li Zhao | Summary: Abstract Understanding phenotypic sex differences has long been a goal of biology from both a medical and evolutionary perspective. Although much attention has been paid to mean differences in phenotype between […]


Continue.. Sex differences in inter-individual gene expression variability across human tissues

Encoding of Dynamic Facial Information in the Middle Dorsal Face Area

Kavli Affiliate: Winrich Freiwald | Authors: Zetian Yang and Winrich A. Freiwald | Summary: Abstract Faces in motion reveal a plethora of information through visual dynamics. Faces can move in complex patterns while transforming facial shape, e.g. during the generation of different emotional expressions. While motion and shape processing have been studied extensively in separate […]


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The energetics of rapid cellular mechanotransduction

Kavli Affiliate: Michael Young | Authors: Michael N Young, Michael J Sindoni, Amanda H Lewis, Stefan Zauscher and Jorg Grandl | Summary: Cells throughout the human body detect mechanical forces. While it is known that the rapid (millisecond) detection of mechanical forces is mediated by force-gated ion channels, a detailed quantitative understanding of cells as […]


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A Draft Human Pangenome Reference

Kavli Affiliate: Erich Jarvis | Authors: Wen-Wei Liao, Mobin Asri, Jana Ebler, Daniel Doerr, Marina Haukness, Glenn Hickey, Shuangjia Lu, Julian K. Lucas, Jean Monlong, Haley J. Abel, Silvia Buonaiuto, Xian H. Chang, Haoyu Cheng, Justin Chu, Vincenza Colonna, Jordan M. Eizenga, Xiaowen Feng, Christian Fischer, Robert S. Fulton, Shilpa Garg, Cristian Groza, Andrea Guarracino, […]


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Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

Kavli Affiliate: Jean Laurent Casanova | Authors: Gaspard Kerner, Anna-Lena Neehus, Laurent Abel, Jean-Laurent Casanova, Etienne Patin, Guillaume Laval and Lluis Quintana-Murci | Summary: Ancient genomics can directly detect human genetic adaptation to environmental cues. However, it remains unclear how pathogens have exerted selective pressures on human genome diversity across different epochs and affected present-day […]


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Convergent gene expression highlights shared vocal motor microcircuitry in songbirds and humans

Kavli Affiliate: Erich Jarvis | Authors: Gregory L Gedman, Matthew T Biegler, Bettina Haase, Morgan Wirthlin, Olivier Fedrigo, Andreas R Pfenning and Erich D Jarvis | Summary: Vocal learning is a skilled motor behavior observed in several mammalian and avian species and is critical for human speech. While convergent gene expression patterns have highlighted similar […]


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Quantitative prediction and measurement of Piezo’s membrane footprint

Kavli Affiliate: Roderick MacKinnon | Authors: Christoph A. Haselwandter, Roderick MacKinnon, Yusong Guo and Ziao Fu | Summary: Piezo proteins are mechanosensitive ion channels that can locally curve the membrane into a dome shape (Y. R. Guo, R. MacKinnon, 2017). The curved shape of the Piezo dome is expected to deform the surrounding lipid bilayer […]


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Differential sensory and immune gene evolution in sea turtles with contrasting demographic and life histories

Kavli Affiliate: Erich Jarvis | Authors: Blair P Bentley, Tomás Carrasco-Valenzuela, Elisa K. S. Ramos, Harvinder Pawar, Larissa Souza Arantes, Alana Alexander, Shreya M Banerjee, Patrick Masterson, Martin Kuhlwilm, Martin Pippel, Jacquelyn Mountcastle, Bettina Haase, Marcela Uliano Silva, Giulio Formenti, Kerstin Howe, William Chow, Alan Tracey, Yumi Sims, Sarah Pelan, Jonathan Wood, Kelsey Yetsko, Justin […]


Continue.. Differential sensory and immune gene evolution in sea turtles with contrasting demographic and life histories