Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Ekaterina Vinogradova, Alisa Mikhaylina, Oleg Nikonov and Ekaterina Nikonova | Summary: Aminoacyl-tRNA synthetases (aaRS) are the main enzymes of protein biosynthesis. Human glycyl-tRNA synthetase, in addition to the main function of amino acid transfer to the corresponding tRNA molecules, is also involved in the initiation of IRES I […]

Kavli Affiliate: Alipasha Vaziri | Authors: Tobias Nöbauer, Yuanlong Zhang, Hyewon Kim and Alipasha Vaziri | Summary: Various implementations of mesoscopes provide optical access for calcium imaging across multi-millimeter fields-of-view (FOV) in the mammalian brain. However, capturing the activity of the neuronal population within such FOVs near-simultaneously and in a volumetric fashion has remained challenging […]

Kavli Affiliate: Charles M. Rice | Authors: Ariane J Brown, John Won, Raphael Wolfisberg, Ulrik Fanhoe, Nicholas Catanzaro, Ande West, Fernando Moreira, Mariana Nogeuira Batista, Martin T. Ferris, Colton Linnertz, Sarah R Leist, Cameron Nguyen, Gabriella De la Cruz, Bentley Midkiff, Yongjuan Xia, Stephanie A Montgomery, Eva Billerbeck, Jens Bukh, Troels Scheel, Charles M Rice […]

Kavli Affiliate: Michael W. Young | Authors: Yi Sun, Michael C Young, Claire H Woodward, Julia N Danon, Hau V Truong, Sagar Gupta, Trenton J Winters, George Burslem and Nikolaos G Sgourakis | Summary: The polymorphic nature and intrinsic instability of class I major histocompatibility complex (MHC-I) and MHC-like molecules loaded with suboptimal peptides, metabolites, […]

Kavli Affiliate: Erich Jarvis | Authors: Farooq Omar Al-Ajli, Giulio Formenti, Olivier Fedrigo, Alan Tracey, Ying Sims, Kerstin Howe, Ikdam Karkhi, Asmaa Althani, Erich Jarvis, Sadequr Rahman and Qasim Ayub | Summary: The taxonomic classification of a falcon population found in the Altai region in Asia has been heavily debated for two centuries and previous […]

Kavli Affiliate: A. James Hudspeth | Authors: Agnik Dasgupta, Caleb C. Reagor, Sang Peter Paik, Lauren M Snow, Adrian Jacobo and Albert Hudspeth | Summary: In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory […]

Kavli Affiliate: Robert B. Darnell | Authors: Leena Ali Ibrahim, Brie Wamsley, Norah Alghamdi, Nusrath Yusuf, Elaine Sevier, Ariel Hairston, Mia Sherer, Xavier Hubert Jaglin, Qing Xu, Lijua Gao, Alireza Khodadadi-Jamayran, Emilia Favuzzi, Yuan Yuan, Jordane Dimidschstein, Robert Darnell and Gordon Fishell | Summary: Somatostatin interneurons are the earliest born population of cortical inhibitory cells. […]

Kavli Affiliate: Mary E. Hatten, C. David Allis | Authors: Kärt Mätlik, Eve-Ellen Govek, Matthew R. Paul, C. David Allis and Mary E. Hatten | Summary: Abstract Developing neurons undergo a progression of morphological and gene expression changes as they transition from neuronal progenitors to mature, multipolar neurons. Here we use RNA-seq and H3K4me3 and […]

Kavli Affiliate: Timothy A. Ryan | Authors: Mukesh Kumar, Justin Knapp, Kallol Gupta and Timothy A Ryan | Summary: Recent advances have expanded the role of lipid droplets (LDs) beyond passive lipid storage, implicating their involvement in various metabolic processes across mammalian tissues. Neuronal LDs, long debated in existence, have been identified in several neural […]

Kavli Affiliate: Thomas P. Sakmar | Authors: Ilana B. Kotliar, Emilie Ceraudo, Kevin Kemelmakher-Liben, Deena A. Oren, Emily Lorenzen, Tea Dodig-Crnković, Mizuho Horioka-Duplix, Thomas Huber, Jochen M. Schwenk and Thomas P. Sakmar | Summary: Abstract Cholestatic itch is a severe and debilitating symptom in liver diseases with limited treatment options. The class A G protein-coupled […]