Loss of functional heterogeneity along the CA3 transverse axis in aging

Posted by klaurent Hopkins

Kavli Affiliate: Michela Gallagher, James Knierim | Authors: Heekyung Lee, Zitong Wang, Arjuna Tilekeratne, Nick Lukish, Scott Zeger, Michela Gallagher and James J Knierim | Summary: Age-related deficits in pattern separation have been postulated to bias the output of hippocampal memory processing toward pattern completion, which can cause deficits in accurate memory retrieval. While the […]


Continue.. Loss of functional heterogeneity along the CA3 transverse axis in aging

Cyclic, condition-independent activity in primary motor cortex predicts corrective movement behavior

Posted by klaurent Hopkins

Kavli Affiliate: Sridevi Sarma | Authors: Adam G Rouse, Marc H Schieber and Sridevi V Sarma | Summary: Reaching movements are known to have large condition-independent neural activity and cyclic neural dynamics. A new precision center-out task was performed by rhesus macaques to test the hypothesis that cyclic, condition-independent neural activity in the primary motor […]


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Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths that are vulnerable to degeneration with age

Posted by klaurent Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Cody L. Call, Sarah A. Neely, Jason J. Early, Owen G. James, Lida Zoupi, Anna C. Williams, Siddharthan Chandran, David A. Lyons and Dwight E. Bergles | Summary: Myelin sheaths in the CNS are generated by the tips of oligodendrocyte processes, which wrap axons to accelerate action potential conduction, […]


Continue.. Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths that are vulnerable to degeneration with age

Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons

Posted by klaurent Hopkins

Kavli Affiliate: Jin Kang | Authors: McSweeney, Rafael Gabriel, Kang Jin, Zhiping P. Pang, Bruce Aronow and ChangHui Pak | Summary: Loss-of-function (LOF) mutations in CASK cause severe developmental phenotypes, including microcephaly with pontine and cerebellar hypoplasia, X-linked intellectual disability, and autism. Unraveling the pathogenesis of CASK-related disorders has been challenging due to limited human […]


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Using Biological Constraints to Improve Prediction in Precision Oncology

Posted by klaurent Hopkins

Kavli Affiliate: Donald Geman, Laurent Younes | Authors: Mohamed Omar, Wikum Dinalankara, Lotte Mulder, Tendai Coady, Claudio Zanettini, Eddie Luidy Imada, Laurent Younes, Donald Geman and Luigi Marchionni | Summary: Abstract Many gene signatures have been developed by applying machine learning (ML) on omics profiles, however, their clinical utility is often hindered by limited interpretability […]


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Age-specific mechanisms regulate neural crest and mesodermal contribution to the enteric nervous system in health and disease

Posted by klaurent Hopkins

Kavli Affiliate: Loyal Goff | Authors: Subhash Kulkarni, Monalee Saha, Alpana Singh, Jared Slosberg, Sushma Nagaraj, Laren S Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna Leser, Mithra Kumar, Shriya Bakhshi, Matthew J Anderson, Mark Lewandoski, Elizabeth Vincent, Loyal Goff and Pankaj Jay Pasricha | Summary: Abstract The enteric nervous system (ENS), a […]


Continue.. Age-specific mechanisms regulate neural crest and mesodermal contribution to the enteric nervous system in health and disease