Kavli Affiliate: Menno Witter, Susumu Mori, Michael Miller | Authors: Kaitlin Stouffer, Claire Chen, Sue Kulason, Eileen Xu, Menno Witter, Can Ceritoglu, Marilyn Albert, Susumu Mori, Juan Troncoso, Daniel Jacob Tward and Michael I Miller | Summary: Previous research has emphasized the unique impact of Alzheimer’s Disease (AD) pathology on the medial temporal lobe (MTL), […]
Kavli Affiliate: Loyal Goff | Authors: Shijie C. Zheng, Genevieve Stein-O’Brien, Leandros Boukas, Loyal A Goff and Kasper D Hansen | Summary: RNA velocity analysis of single cells promises to predict temporal dynamics from gene expression. Indeed, in many systems, it has been observed that RNA velocity produces a vector field which qualitatively reflects known […]
Kavli Affiliate: Patrick Kanold | Authors: Binghan Xue, Joseph P-Y Kao and Patrick O Kanold | Summary: A common impairment in aging is age-related hearing loss (presbycusis), which manifests as impaired spectrotemporal processing. Aging is accompanied by alteration in normal inhibitory (GABA) neurotransmission and changes in excitatory (NMDA and AMPA) synapses in the auditory cortex […]
Kavli Affiliate: James Knierim | Authors: Manu S Madhav, Ravikrishnan P Jayakumar, Brian Y Li, Francesco Savelli, James J Knierim and Noah J Cowan | Summary: Understanding the interplay between sensory input, endogenous neural dynamics, and behavioral output is key toward understanding the principles of neural computation. Hippocampal place cells are an ideal system to […]
Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Hasti Atashi and Solomon Snyder | Summary: The adult subventricular zone is one of the two neurogenic niches that continuously produce newborn neurons. Here we show that serine racemase (SR), an enzyme that catalyzes the racemization of L-serine to D-serine and vice versa, affects neurogenesis in the […]
Kavli Affiliate: James Knierim | Authors: William Hockeimer, Ruo-Yah Lai, Maanasa Natrajan, William Snider and James J. Knierim | Summary: The hippocampus is believed to encode episodic memory by binding information about the content of experience within a spatial framework encoding the location of that experience. Previous work implies a distinction between positional inputs to […]
Kavli Affiliate: Michael Miller | Authors: Blake R Neyland, Samuel N Lockhart, Robert G Lyday, Laura D Baker, Elizabeth P Handing, Michael E Miller, Stephen B Kritchevsky, Paul J Laurienti and Christina E Hugenschmidt | Summary: BACKGROUND: Physical resilience with age is considered a key feature of healthy aging, but current understanding of the neural […]
Kavli Affiliate: Carey Priebe, Joshua Vogelstein | Authors: Benjamin D Pedigo, Michael Winding, Carey E Priebe and Joshua T Vogelstein | Summary: Graph matching algorithms attempt to find the best correspondence between the nodes of two networks. These techniques have previously been used to match individual neurons in nanoscale connectomes – in particular, to find […]
Kavli Affiliate: Jin Kang | Authors: Minzhe Guo, Michael P. Morley, Yixin Wu, Yina Du, Shuyang Zhao, Andrew Wagner, Michal Kouril, Kang Jin, Nathan Gaddis, Joseph A. Kitzmiller, Kathleen Stewart, Maria C. Basil, Susan M. Lin, Yun Ying, Apoorva Babu, Kathryn A. Wikenheiser-Brokamp, Kyu Shik Mun, Anjaparavanda P. Naren, Sara Lin, Geremy Clair, Joshua N. […]
Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Moataz M Gadalla, Lauren Albacarys, Timothy West, Harry Saavedra, Leon Mario Amzel and Solomon H. Snyder | Summary: Endogenous D-stereoisomers are being recognized as functionally important molecules in mammals. Here we report the first identification of endogenous D-cysteine in mammalian pancreas. Serine Racemase (SR) is the biosynthetic […]