Kavli Affiliate: Joshua Vogelstein | Authors: Aki Nikolaidis, Andrew An Chen, Xiaoning He, Russell Shinohara, Joshua Vogelstein, Michael Milham and Haochang Shou | Summary: Biomarkers of behavior and psychiatric illness for cognitive and clinical neuroscience remain out of reach. Suboptimal reliability of biological measurements, such as functional magnetic resonance imaging (fMRI), is increasingly cited as […]
Kavli Affiliate: Denis Wirtz | Authors: Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell, Jacquelyn W Zimmerman, Denis Wirtz, Elizabeth M. Jaffee, Laura D. Wood, Elana J. Fertig and Luciane […]
Kavli Affiliate: Denis Wirtz | Authors: Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell, Jacquelyn W Zimmerman, Denis Wirtz, Elizabeth M. Jaffee, Laura D. Wood, Elana J. Fertig and Luciane […]
Kavli Affiliate: Richard Huganir | Authors: William Dylan Hale, Thomas C. Sudhof and Richard L. Huganir | Summary: In multicellular organisms, cell-adhesion molecules connect cells into tissues and mediate intercellular signaling between these cells. In vertebrate brains, synaptic cell-adhesion molecules (SAMs) guide the formation, specification, and plasticity of synapses. Some SAMs, when overexpressed in cultured […]
Kavli Affiliate: Kathleen Cullen | Authors: Cynthia R Steinhardt, Diana E Mitchell, Kathleen E Cullen and Gene Y Fridman | Summary: Electrical stimulation of neural responses is used both scientifically in brain mapping studies and in many clinical applications such as cochlear, vestibular, and retinal implants. Due to safety considerations, stimulation of the nervous system […]
Kavli Affiliate: David Linden | Authors: Friederike Ehrhart, Ana Silva, Therese Amelsvoort, Emma von Scheibler, Chris Evelo and David E.J. Linden | Summary: Schizophrenia genetics is complex, and the contribution of common and rare variants are not fully understood. Several specific copy number variations (CNVs) confer increased risk for schizophrenia, and the study of their […]
Kavli Affiliate: Loyal Goff | Authors: Jeanette Anna Irene Johnson, Ashley Tsang, Jacob T Mitchell, Emily F Davis-Marcisak, Thomas Sherman, Ted Liefeld, Melanie Loth, Loyal Goff, Jacquelyn Zimmerman, Ben Kinny-Köster, Elizabeth Jaffee, Pablo Tamayo, Jill Mesirov, Michael Reich, Elana J Fertig and Genevieve L Stein-O’Brien | Summary: Non-negative matrix factorization (NMF) is an unsupervised learning […]
Kavli Affiliate: Peter Searson | Authors: Zhaobin Guo, Nan Zhao, Tracy D. Chung, Anjan Singh, Ikshu Pandey, Linus Wang, Xinyue Gu, Aisha Ademola, Raleigh Miller Linville, Utpal Pal, J. Stephen Dumler and Peter C. Searson | Summary: Lyme disease is a tick-borne disease prevalent in North America, Europe, and Asia. Dissemination of vector-borne pathogens, such […]
Kavli Affiliate: Dwight Bergles | Authors: Calvin J Kersbergen, Travis A Babola, Jason Rock and Dwight E Bergles | Summary: Neurons that process sensory information exhibit bursts of electrical activity during development, providing early training to circuits that will later encode similar features of the external world. In the mammalian auditory system, this intrinsically generated […]
Kavli Affiliate: Loyal Goff | Authors: Shijie C. Zheng, Genevieve Stein-O’Brien, Leandros Boukas, Loyal A Goff and Kasper D Hansen | Summary: RNA velocity analysis of single cells promises to predict temporal dynamics from gene expression. Indeed, in many systems, it has been observed that RNA velocity produces a vector field that qualitatively reflects known […]