Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

Kavli Affiliate: Keri Martinowich | Authors: Louise A. Huuki-Myers, Abby Spangler, Nicholas J. Eagles, Kelsey D. Montgomery, Sang Ho Kwon, Boyi Guo, Melissa Grant-Peters, Heena R. Divecha, Madhavi Tippani, Chaichontat Sriworarat, Annie B. Nguyen, Prashanthi Ravichandran, Matthew N. Tran, Arta Seyedian, PsychENCODE Consortium, Thomas M. Hyde, Joel E. Kleinman, Alexis Battle, Stephanie C. Page, Mina […]


Continue.. Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

Mapping Neurophysiological Subtypes of Major Depressive Disorder Using Normative Models of the Functional Connectome

Kavli Affiliate: Xiaoqin Wang | Authors: Xiaoyi Sun, Jin Liu, Qing Ma, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Wenxu Wang, Yong […]


Continue.. Mapping Neurophysiological Subtypes of Major Depressive Disorder Using Normative Models of the Functional Connectome

MISPEL: A deep learning approach for harmonizing multi-scanner matched neuroimaging data

Kavli Affiliate: Ciprian Crainiceanu | Authors: Mahbaneh Eshaghzadeh Torbati, Davneet S Minhas, Charles M Laymon, Pauline Maillard, James D Wilson, Chang-Le Chen, Ciprian M Crainiceanu, Charles S DeCarli, Seong Jae Hwang and Dana L Tudorascu | Summary: Abstract Large-scale data obtained from aggregation of already collected multi-site neuroimaging datasets has been brought benefits such as […]


Continue.. MISPEL: A deep learning approach for harmonizing multi-scanner matched neuroimaging data

Auditory memory of complex sounds in sparsely distributed, highly correlated neurons in the auditory cortex

Kavli Affiliate: Patrick Kanold | Authors: HiJee Kang and Patrick O Kanold | Summary: Listening in complex sound environments requires rapid segregation of different sound sources e.g., speakers from each other, speakers from other sounds, or different instruments in an orchestra, and also adjust auditory processing on the prevailing sound conditions. Thus, fast encoding of […]


Continue.. Auditory memory of complex sounds in sparsely distributed, highly correlated neurons in the auditory cortex

Performant web-based interactive visualization tool for spatially-resolved transcriptomics experiments

Kavli Affiliate: Keri Martinowich | Authors: Chaichontat Sriworarat, Annie B. Nguyen, Nicholas J. Eagles, Leonardo Collado-Torres, Keri Martinowich, Kristen R. Maynard and Stephanie C. Hicks | Summary: High-resolution and multiplexed imaging techniques are giving us an increasingly detailed observation of a biological system. However, sharing, exploring, and customizing the visualization of large multidimensional images can […]


Continue.. Performant web-based interactive visualization tool for spatially-resolved transcriptomics experiments

Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

Kavli Affiliate: Denis Wirtz | Authors: Alicia M Braxton, Ashley L Kiemen, Mia P Grahn, Andre Forjaz, Jaanvi Mahesh Babu, Lily Zheng, Liping Jiang, Haixia Cheng, Qianqian Song, Rebecca Reichel, Sarah Graham, Alexander I Damanakis, Catherine G Fischer, Stephanie Mou, Cameron Metz, Julie Granger, Xiao-Ding Liu, Niklas Bachmann, Cristina Almagro-Perez, Ann Chenyu Jiang, Jeonghyun Yoo, […]


Continue.. Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

Hierarchical Deviant Processing in Auditory Cortex of Awake Mice

Kavli Affiliate: Patrick Kanold | Authors: Dan Luo, Ji Liu, Ryszard Auksztulewicz, Tony Ka Wing Yip, Patrick O. Kanold and Jan W. Schnupp | Summary: Detecting patterns, and noticing unexpected pattern changes, in the environment is a vital aspect of sensory processing. Adaptation and prediction error responses are two components of neural processing related to […]


Continue.. Hierarchical Deviant Processing in Auditory Cortex of Awake Mice

Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

Kavli Affiliate: Jeremy Nathans | Authors: Jie Wang, Amir Rattner and Jeremy Nathans | Summary: Bacterial meningitis is a major cause of morbidity and mortality, especially among infants and the elderly. Here we study mice to assess the response of each of the major meningeal cell types to early postnatal E. coli infection using single […]


Continue.. Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

Kavli Affiliate: Denis Wirtzr | Authors:Adrian C. Johnston, Gretchen M. Alicea, Cameron C. Lee, Payal V. Patel, Eban A. Hanna, Eduarda Vaz, Andre Forjaz, Zeqi Wan, Praful R. Nair, Yeongseo Lim, Tina Chen, Wenxuan Du, Dongjoo Kim, Tushar D. Nichakawade, Vito W. Rebecca, Challice L. Bonifant, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu and Denis […]


Continue.. Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

Multi-center integrated analysis of non-coding CRISPR screens

Kavli Affiliate: Michael Beer | Authors: David Yao, Josh Tycko, Woo Oh, Lexi R. Bounds, Sager J. Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R. Doughty, Idan Gabdank, Henri Schmidt, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunahi Luo, Keith Siklenka, Galip Gurkan Yardimci, The ENCODE4 Consortium, Ryan Tewhey, Anshul Kundaje, William J. Greenleaf, Pardis […]


Continue.. Multi-center integrated analysis of non-coding CRISPR screens