A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

Kavli Affiliate: Seth Blackshaw | Authors: Marysia Placzek, Kavitha Chinnaiya, Sarah Burbridge, Aragorn Jones, Dong Won Kim, Elsie Place, Elizabeth Manning, Ian Groves, Changyu Sun, Matthew Towers and Seth Blackshaw | Summary: Abstract The tuberal hypothalamus houses several major hypothalamic nuclei, dozens of transcriptionally distinct cell types, and clinically relevant cell populations implicated in obesity […]


Continue.. A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

Norepinephrine enhances oligodendrocyte precursor cell calcium dynamics in the cerebral cortex during arousal

Kavli Affiliate: Dwight Bergles | Authors: Tsai-Yi Lu, Priyanka Hanumaihgari, Eric T Hsu, Amit Agarwal and Dwight E Bergles | Summary: Abstract Oligodendrocytes are generated from a widely distributed population of progenitors that express neurotransmitter receptors, but the mechanisms that alter activity of these oligodendrocyte precursor cells (OPCs) in vivo have not been determined. We […]


Continue.. Norepinephrine enhances oligodendrocyte precursor cell calcium dynamics in the cerebral cortex during arousal

Single cell transcriptomic profiling of human brain organoids reveals developmental timing- and cell-type-specific vulnerabilities induced by NRXN1 CNVs in schizophrenia

Kavli Affiliate: Jin Kang | Authors: ChangHui Pak, Rebecca Sebastian, Kang Jin, Narciso Pavon, Ruby Bansal, Andrew Potter, Yoonjae Song, Juliana Babu, Rafael Gabriel, Yubing Sun and Bruce J Aronow | Summary: Abstract De novo mutations and copy number variations (CNVs) in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). How NRXN1 CNVs impact […]


Continue.. Single cell transcriptomic profiling of human brain organoids reveals developmental timing- and cell-type-specific vulnerabilities induced by NRXN1 CNVs in schizophrenia

Age-dependent changes in the dynamic functional organization of the brain at rest – a cross – cultural replication approach

Kavli Affiliate: David Linden | Authors: Xi Yang, Xinqi Zhou, Fei Xin, Benjamin Becker, David Linden and Dennis Hernaus | Summary: Abstract Age-associated changes in brain function play an important role in the development of neurodegenerative diseases. Although previous work has examined age-related changes in static functional connectivity (FC), accumulating evidence suggests that advancing age […]


Continue.. Age-dependent changes in the dynamic functional organization of the brain at rest – a cross – cultural replication approach

Internal states as a source of subject-dependent movement variability and their representation by large-scale networks

Kavli Affiliate: Kathleen Cullen & Sridevi Sarma | Authors: Macauley Smith Breault, Pierre Sacré, Zachary B Fitzgerald, John T Gale, Kathleen E Cullen, Jorge A González-Martínez and Sridevi V Sarma | Summary: Abstract A human’s ability to adapt and learn relies on reflecting on past performance. Such reflections form latent factors called internal states that […]


Continue.. Internal states as a source of subject-dependent movement variability and their representation by large-scale networks

From Prediction to Action: Dissociable Roles of Ventral Tegmental Area and Substantia Nigra Dopamine Neurons in Instrumental Reinforcement

Kavli Affiliate: Patricia Janak | Authors: Kurt Michael Fraser, Heather J Pribut, Patricia H Janak and Ronald Keiflin | Summary: Abstract Reward-seeking requires the coordination of motor programs to achieve goals. Midbrain dopamine neurons are critical for reinforcement and their activation is sufficient for learning about cues, actions, and outcomes. Here we examine in detail […]


Continue.. From Prediction to Action: Dissociable Roles of Ventral Tegmental Area and Substantia Nigra Dopamine Neurons in Instrumental Reinforcement

Object representation in a gravitational reference frame

Kavli Affiliate: Kristina Nielsen and Charles Connor | Authors: Alexandriya MX Emonds, Ramanujan Srinath, Kristina J Nielsen and Charles E Connor | Summary: ABSTRACT When your head tilts laterally, as in sports, reaching, and resting, your eyes counterrotate less than 20%, and thus eye images rotate, over a total range of about 180°. Yet, the […]


Continue.. Object representation in a gravitational reference frame

Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters

Kavli Affiliate: Patricia Janak | Authors: Kurt M Fraser and Patricia H Janak | Summary: ABSTRACT Reward-seeking in the world is driven by cues that can have ambiguous predictive and motivational value. To produce adaptive, flexible reward-seeking it is necessary to exploit occasion setters, other distinct features in the environment, to resolve the ambiguity of […]


Continue.. Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters

Suboptimal phenotypic reliability impedes reproducible human neuroscience

Kavli Affiliate: Joshua Vogelstein | Authors: Aki Nikolaidis, Andrew An Chen, Xiaoning He, Russell Shinohara, Joshua Vogelstein, Michael Milham and Haochang Shou | Summary: Biomarkers of behavior and psychiatric illness for cognitive and clinical neuroscience remain out of reach. Suboptimal reliability of biological measurements, such as functional magnetic resonance imaging (fMRI), is increasingly cited as […]


Continue.. Suboptimal phenotypic reliability impedes reproducible human neuroscience

PanIN and CAF Transitions in Pancreatic Carcinogenesis Revealed with Spatial Data Integration

Kavli Affiliate: Denis Wirtz | Authors: Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell, Jacquelyn W Zimmerman, Denis Wirtz, Elizabeth M. Jaffee, Laura D. Wood, Elana J. Fertig and Luciane […]


Continue.. PanIN and CAF Transitions in Pancreatic Carcinogenesis Revealed with Spatial Data Integration