Guided construction of single cell reference for human and mouse lung

Kavli Affiliate: Jin Kang | Authors: Minzhe Guo, Michael P. Morley, Yixin Wu, Yina Du, Shuyang Zhao, Andrew Wagner, Michal Kouril, Kang Jin, Nathan Gaddis, Joseph A. Kitzmiller, Kathleen Stewart, Maria C. Basil, Susan M. Lin, Yun Ying, Apoorva Babu, Kathryn A. Wikenheiser-Brokamp, Kyu Shik Mun, Anjaparavanda P. Naren, Sara Lin, Geremy Clair, Joshua N. […]


Continue.. Guided construction of single cell reference for human and mouse lung

Serine Racemase is a Cysteine Racemase and Physiologic Down Regulator of Insulin Promoter Methylation

Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Moataz M Gadalla, Lauren Albacarys, Timothy West, Harry Saavedra, Leon Mario Amzel and Solomon H. Snyder | Summary: Endogenous D-stereoisomers are being recognized as functionally important molecules in mammals. Here we report the first identification of endogenous D-cysteine in mammalian pancreas. Serine Racemase (SR) is the biosynthetic […]


Continue.. Serine Racemase is a Cysteine Racemase and Physiologic Down Regulator of Insulin Promoter Methylation

Transretinal migration of astrocytes and brain/spinal cord-like cells arising from transplanted human retinal organoids.

Kavli Affiliate: Seth Blackshaw | Authors: Ying Liu, Clayton Santiago, Akin Sogunro, Gregory K. Konar, Ming-Wen Hu, Minda M. McNally, Yuchen Lu, Zhuolin Li, Dzhalal Agakishiev, Sarah Hadyniak, Katarzyna Hussey, Tyler J. Creamer, Linda D. Orzolek, Derek Teng, Jiang Qian, Zheng Jiang, Robert J. Johnston, Jr., Seth Blackshaw and Mandeep S. Singh | Summary: Human […]


Continue.. Transretinal migration of astrocytes and brain/spinal cord-like cells arising from transplanted human retinal organoids.

Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

Kavli Affiliate: Peter Searson | Authors: Raleigh M. Linville, Matthew B. Sklar, Gabrielle N. Grifno, Renee F. Nerenberg, Justin Zhou, Robert Ye, Jackson G. DeStefano, Zhaobin Guo, Ria Jha, John J. Jamieson, Nan Zhao and Peter C. Searson | Summary: The blood-brain barrier (BBB) plays a pivotal role in brain health and disease. In the […]


Continue.. Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

The lateral habenula mediates the association of a conditioned stimulus with the absence of an appetitive unconditioned stimulus

Kavli Affiliate: Michela Gallagher | Authors: Dong-Hee Kim, In-Beom Jin, Nam-Heon Kim, Yong-Jae Jeon, Bo-Ryoung Choi, Michela Gallagher and Jung-Soo Han | Summary: The lateral habenula (LHb) has been implicated in conditioned inhibition. Here, the modulating effects of LHb activity on the association of a conditioned stimulus (CS) with the nonoccurrence of an unconditioned stimulus […]


Continue.. The lateral habenula mediates the association of a conditioned stimulus with the absence of an appetitive unconditioned stimulus

Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

Kavli Affiliate: David Linden | Authors: J. Kopal, K. Kumar, K. Saltoun, C. Modenato, C. A. Moreau, S. Martin-Brevet, G. Huguet, M. Jean-Louis, C.O. Martin, Z. Saci, N. Younis, P. Tamer, E. Douard, A. M. Maillard, B. Rodriguez-Herreros, A. Pain, S. Richetin, 16p11.2 European Consortium, Simons Searchlight Consortium, L. Kushan, A. I. Silva, M. B. […]


Continue.. Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

Projective LDDMM: Mapping Molecular Digital Pathology with Tissue MRI

Kavli Affiliate: Michael Miller, Menno Witter | Authors: Kaitlin Stouffer, Menno Witter, Daniel Tward and Michael Miller | Summary: Reconstructing dense 3D anatomical coordinates from 2D projective measurements has become a central problem in both mouse and human digital pathology. We describe a new family of diffeomorphic mapping technologies called Projective LDDMM which generate diffeomorphic […]


Continue.. Projective LDDMM: Mapping Molecular Digital Pathology with Tissue MRI

Ret loss-of-function decreases enteric neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system development

Kavli Affiliate: Loyal Goff | Authors: Elizabeth Vincent, Sumantra Chatterjee, Gabrielle H Cannon, Dallas Auer, Holly Ross, Aravinda Chakravarti and Loyal A Goff | Summary: The receptor tyrosine kinase gene RET plays a critical role in the fate specification of enteric neural crest-derived cells (ENCDCs) during enteric nervous system (ENS) development. Pathogenic RET loss of […]


Continue.. Ret loss-of-function decreases enteric neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system development

Glutamatergic projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in a mouse model of depression

Kavli Affiliate: Paul Greengard | Authors: Ana Milosevic, Lucian Medrihan, Margarete Knudsens, Tatiana Ferraro, Pedro Del Cioppo Vasques, Yevgeniy Romin, Sho Fujisawa and Paul Greengard | Summary: The cholinergic interneurons (ChATs) of the nucleus accumbens (NAc) have a critical role in the activity of this region, specifically in the context of major depressive disorder. To […]


Continue.. Glutamatergic projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in a mouse model of depression

Shell Microelectrode Arrays (MEAs) for brain organoids

Kavli Affiliate: Brian Caffo | Authors: Qi Huang, Bohao Tang, July Carolina Romero, Yuqian Yang, Saifeldeen Khalil Elsayed, Gayatri Pahapale, Tien-Jung Lee, Itzy Erin Morales Pantoja, Fang Han, Cynthia Berlinicke, Terry Xiang, Mallory Solazzo, Thomas Hartung, Zhao Qin, Brian Caffo, Lena Smirnova and David H Gracias | Summary: Brain organoids are important models for mimicking […]


Continue.. Shell Microelectrode Arrays (MEAs) for brain organoids