Kavli Affiliate: Donald Geman, Laurent Younes | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Accurate identification of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. Such analyses […]

Kavli Affiliate: Keri Martinowich | Authors: Svitlana V Bach, Allison J Bauman, Darya Hosein, Jennifer J Tuscher, Lara Ianov, Kelsey M Greathouse, Benjamin W Henderson, Jeremy H. Herskowitz, Keri Martinowich and Jeremy J Day | Summary: Brain-derived neurotrophic factor (Bdnf) plays a critical role in brain development, dendritic growth, synaptic plasticity, as well as learning […]

Kavli Affiliate: Loyal Goff | Authors: Subhash Kulkarni, Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Laren S Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna Leser, Mithra Kumar, Shriya Bakhshi, Matthew J Anderson, Mark Lewandoski, Elizabeth Vincent, Loyal Goff and Pankaj Jay Pasricha | Summary: The enteric nervous system (ENS), a collection […]

Kavli Affiliate: Joshua Vogelstein | Authors: Jaewon Chung, Eric W Bridgeford, Michael Powell and Joshua T Vogelstein | Summary: The heritability of human connectomes is crucial for understanding the genetic and environmental factors that influence variations in connectomes, which can provide insights into behavior and disease. However, current approaches to studying connectome heritability assume an […]

Kavli Affiliate: Laurent Younes, Michael Miller, Jean Fan | Authors: Kaitlin M Stouffer, Alain Trouve, Laurent Younes, Michael Kunst, Lydia Ng, Hongkui Zeng, Manjari Anant, Jean Fan, Yongsoo Kim and Michael I Miller | Summary: This paper explicates a solution to the problem of building correspondences between molecular-scale transcriptomics and tissue-scale atlases. The central model […]

Kavli Affiliate: David Linden | Authors: Xi Yang, Yixu Zeng, Guojuan Jiao, Xiyang Gan, David Linden, Dennis Hernaus, Chaoze Zhu, Keshuang Li, Dezhong Yao, Shuxia Yao, Yihan Jiang and Benjamin Becker | Summary: Working memory (WM) represents a building-block of higher cognitive functions and a wide range of mental disorders are associated with WM impairments. […]

Kavli Affiliate: Brian Caffo, Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Batch effects, undesirable sources of variance across multiple experiments, present a substantial hurdle for scientific and clinical discoveries. Specifically, the […]

Kavli Affiliate: Michael Beer | Authors: Renhe Luo, Jielin Yan, Jin Woo Oh, Wang Xi, Dustin Shigaki, Wilfred Wong, Hyunwoo Cho, Dylan Murphy, Ronald Cutler, Bess P. Rosen, Julian Pulecio, Dapeng Yang, Rachel Glenn, Tingxu Chen, Qing V. Li, Thomas Vierbuchen, Simone Sidoli, Effie Apostolou, Danwei Huangfu and Michael A. Beer | Summary: Comprehensive enhancer […]

Kavli Affiliate: Michael Miller, Joshua Vogelstein | Authors: Thomas Athey, Matthew Wright, Marija Pavlovic, Vikram Chandrashekhar, Karl Deisseroth, Michael Miller and Joshua Vogelstein | Summary: Whole-brain fluorescence images require several stages of computational processing to fully reveal the neuron morphology and connectivity information they contain. However, these computational tools are rarely part of an integrated […]

Kavli Affiliate: Patrick Kanold | Authors: Didhiti Mukherjee, Binghan Xue, Chih-Ting Chen, Minzi Chang, Joseph P-Y. Kao and Patrick O. Kanold | Summary: Sensory perturbation in one modality results in adaptive reorganization of neural pathways within the spared modalities, a phenomenon known as “crossmodal plasticity”, which has been examined during or after the classic ‘critical […]