Kavli Affiliate: Donald Geman, Laurent Younes | Authors: Kun Yang, Koko Ishizuka, Zui Narita, Yukiko Y Lema, Siwei Zhang, Jubao Duan, Laurent Younes, Donald Geman, Andrew P Lane and Akira Sawa | Summary: ABSTRACT Biopsy is an essential procedure of clinical medicine in which we obtain tissues and cells that are supposed to directly reflect […]
Kavli Affiliate: Michael Miller | Authors: MoTrPAC Study Group, David Amar, Nicole R. Gay, Pierre M. Jean Beltran, Joshua N. Adkins, Jose J. Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Nasim Bararpour, Charles Burant, Clary Clish, Gary Cutter, Surendra Dasari, Courtney Dennis, Charles R. Evans, Facundo M. Fernández, David Gaul, Yongchao Ge, Robert Gerszten, […]
Kavli Affiliate: Jin Kang | Authors: Jin Young Kang, Tatiana V Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James Liu, Seth A Darst and Robert Landick | Summary: Abstract Transcriptional pausing underpins regulation of cellular RNA synthesis but its mechanism remains incompletely understood. Sequence-specific interactions of DNA and RNA with the dynamic, multidomain RNA polymerase […]
Kavli Affiliate: James Knierim | Authors: Sang Hoon Kim, Douglas GoodSmith, Stephanie J Temme, Fumika Moriya, Guo-li Ming, Kimberly Christian, Hongjun Song and James J Knierim | Summary: SUMMARY Hippocampal place cells exhibit spatially modulated firing, or place fields, which can remap to encode changes in the environment or other variables. Unique among hippocampal subregions, […]
Kavli Affiliate: Seth Blackshaw | Authors: Marysia Placzek, Kavitha Chinnaiya, Sarah Burbridge, Aragorn Jones, Dong Won Kim, Elsie Place, Elizabeth Manning, Ian Groves, Changyu Sun, Matthew Towers and Seth Blackshaw | Summary: Abstract The tuberal hypothalamus houses several major hypothalamic nuclei, dozens of transcriptionally distinct cell types, and clinically relevant cell populations implicated in obesity […]
Kavli Affiliate: Dwight Bergles | Authors: Tsai-Yi Lu, Priyanka Hanumaihgari, Eric T Hsu, Amit Agarwal and Dwight E Bergles | Summary: Abstract Oligodendrocytes are generated from a widely distributed population of progenitors that express neurotransmitter receptors, but the mechanisms that alter activity of these oligodendrocyte precursor cells (OPCs) in vivo have not been determined. We […]
Kavli Affiliate: Jin Kang | Authors: ChangHui Pak, Rebecca Sebastian, Kang Jin, Narciso Pavon, Ruby Bansal, Andrew Potter, Yoonjae Song, Juliana Babu, Rafael Gabriel, Yubing Sun and Bruce J Aronow | Summary: Abstract De novo mutations and copy number variations (CNVs) in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). How NRXN1 CNVs impact […]
Kavli Affiliate: David Linden | Authors: Xi Yang, Xinqi Zhou, Fei Xin, Benjamin Becker, David Linden and Dennis Hernaus | Summary: Abstract Age-associated changes in brain function play an important role in the development of neurodegenerative diseases. Although previous work has examined age-related changes in static functional connectivity (FC), accumulating evidence suggests that advancing age […]
Kavli Affiliate: Kathleen Cullen & Sridevi Sarma | Authors: Macauley Smith Breault, Pierre Sacré, Zachary B Fitzgerald, John T Gale, Kathleen E Cullen, Jorge A González-Martínez and Sridevi V Sarma | Summary: Abstract A human’s ability to adapt and learn relies on reflecting on past performance. Such reflections form latent factors called internal states that […]
Kavli Affiliate: Patricia Janak | Authors: Kurt Michael Fraser, Heather J Pribut, Patricia H Janak and Ronald Keiflin | Summary: Abstract Reward-seeking requires the coordination of motor programs to achieve goals. Midbrain dopamine neurons are critical for reinforcement and their activation is sufficient for learning about cues, actions, and outcomes. Here we examine in detail […]