Kavli Affiliate: Seth Blackshaw | Authors: Cornelia Peterson, Clayton P. Santiago, Yuchen Lu, Antoinette Price, Minda M. McNally, William Schubert, Seth Blackshaw, Charles G. Eberhart and Mandeep S. Singh | Summary: SUMMARY Purpose Proliferative vitreoretinopathy (PVR) is the most common cause of failure of surgically repaired rhegmatogenous retinal detachment (RRD). Chemically-induced and cell-injection PVR models […]

Kavli Affiliate: Patrick Kanold | Authors: Ji Liu and Patrick O Kanold | Summary: SUMMARY Predictive coding theory postulates that the brain achieves perception by actively making predictions about the incoming sensory information and correcting them if errors signals arise. These signals are likely the most relevant when the individual is actively interacting with the […]

Kavli Affiliate: Jeremiah Cohen | Authors: Zhixiao Su and Jeremiah Y. Cohen | Summary: Abstract The cerebral cortex generates flexible behavior by learning. Reinforcement learning is thought to be driven by error signals in midbrain dopamine neurons. However, they project more densely to basal ganglia than cortex, leaving open the possibility of another source of […]

Kavli Affiliate: Patrick Kanold | Authors: Ji Liu, Kate Maximov and Patrick O Kanold | Summary: Abstract Many animal training paradigms rely on head-fixation. Head-fixation training is typically laborious and can benefit from automation to relieve the workload as well as to reduce the variability in the training outcome. Several groups have reported successful implementations […]

Kavli Affiliate: Carey Priebe, Joshua Vogelstein | Authors: Benjamin D. Pedigo, Mike Powell, Eric W. Bridgeford, Michael Winding, Carey E. Priebe and Joshua T. Vogelstein | Summary: Abstract Comparing connectomes can help explain how neural connectivity is related to genetics, disease, development, learning, and behavior. However, making statistical inferences about the significance and nature of […]

Kavli Affiliate: Paul Greengard | Authors: Ran Zhang, Margarete Knudsen, Pedro Del Cioppo Vasques, Alicja Tadych, Patricia Rodriguez-Rodriguez, Paul Greengard, Jean-Pierre Roussarie, Ana Milosevic and Olga G. Troyanskaya | Summary: Abstract Astrocytes have been shown to play a central role in Alzheimer’s Disease (AD). However, the genes and biological pathways underlying disease manifestation are unknown, […]

Kavli Affiliate: Denis Wirtz | Authors: Ashleigh J. Crawford, Clara Gomez-Cruz, Gabriella C. Russo, Wilson Huang, Isha Bhorkar, Arrate Munoz-Barrutia, Denis Wirtz and Daniel Garcia-Gonzalez | Summary: Abstract Cell proliferation and invasion are two key drivers of tumor progression and are traditionally considered two independent cellular processes regulated by distinct pathways. Through in vitro and […]

Kavli Affiliate: Michael Beer | Authors: Catherine L Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlie K Colenso, Christopher J Schofield, Adrian J Mulholland and James Spencer | Summary: Abstract KPC-2 (Klebsiella pneumoniae carbapenemase-2) is a globally disseminated serine-β-lactamase (SBL) responsible for extensive β-lactam antibiotic resistance in Gram-negative pathogens. SBLs inactivate β-lactams via a mechanism […]

Kavli Affiliate: Michael Miller | Authors: Yang Eric Li, Sebastian Preissl, Michael Miller, Nicholas D. Johnson, Zihan Wang, Henry Jiao, Chenxu Zhu, Zhaoning Wang, Yang Xie, Olivier Poirin, Colin Kern, Antonio Pinto-Duarte, Wei Tian, Kimberly Siletti, Nora Emerson, Julia Osteen, Jacinta Lucero, Lin Lin, Qian Yang, Sarah Espinoza, Quan Zhu, Nathan Zemke, Anna Marie Yanny, […]

Kavli Affiliate: Dwight Bergles | Authors: Zoe J. Looser, Luca Ravotto, Ramona B. Jung, Hauke B. Werner, Torben Ruhwedel, Wiebke Moebius, Dwight E Bergles, L. Felipe Barros, Klaus-Armin Nave, Bruno Weber and Aiman S. Saab | Summary: Abstract The integrity of myelinated axons relies on homeostatic support from oligodendrocytes (OLs), which is essential for brain […]