Kavli Affiliate: Stefano Fusi | Authors: W. Jeffrey Johnston and Stefano Fusi | Summary: Humans and other animals demonstrate a remarkable ability to generalize knowledge across distinct contexts and objects during natural behavior. We posit that this ability to generalize arises from a specific representational geometry, that we call abstract and that is referred to […]
Kavli Affiliate: Michael Shadlen | Authors: Gabriel M Stine, Eric M Trautmann, Danique Jeurissen and Michael N Shadlen | Summary: The brain makes decisions by accumulating evidence until there is enough to stop and choose. Neural mechanisms of evidence accumulation are well established in association cortex, but the site and mechanism of termination is unknown. […]
Kavli Affiliate: Wei Min | Authors: Daniel J.M. Crouch, Jamie R.J. Inshaw, Catherine C. Robertson, Jia-Yuan Zhang, Wei-Min Chen, Suna Onengut-Gumuscu, Antony J. Cutler, Carlo Sidore, Francesco Cucca, Flemming Pociot, Patrick Concannon, Steven S. Rich and John A. Todd | Summary: For polygenic traits, associations with genetic variants can be detected over many chromosome regions, […]
Kavli Affiliate: Ann McDermott | Authors: Kelsey M McCoy and Ann E McDermott | Summary: FtsZ filaments are the major structural component of the bacterial Z-ring and are drivers of bacterial division. While crystal structures for FtsZ from some gram positive bacteria in the presence of GTP-analog like compounds suggest the possibility of a high […]
Kavli Affiliate: Mark Churchland, Michael Shadlen | Authors: Najja J. Marshall, Joshua I. Glaser, Eric M. Trautmann, Elom A. Amematsro, Sean M. Perkins, Michael N. Shadlen, L. F. Abbott, John P. Cunningham and Mark M. Churchland | Summary: Voluntary movement requires communication from cortex to the spinal cord, where a dedicated pool of motor units […]
Kavli Affiliate: Mark Churchland | Authors: Shreya Saxena, Abigail Russo, John Cunningham and Mark M Churchland | Summary: Learned movements can be skillfully performed at different paces. What neural strategies produce this flexibility? Can they be predicted and understood by network modeling? We trained monkeys to perform a cycling task at different speeds, and trained […]
Kavli Affiliate: Wei Min | Authors: Clark D Wells, Kevin Lange, Abigail F Thompson, Wei Min Xu, Sherry G Clendenon, John S Underwood, Peter Harris, Britney-Shea Herbert, James A. Glazier, Angela Wandinger-Ness and Robert L Bacallao | Summary: Despite substantial progress in identifying and understanding causative mutations in autosomal dominant polycystic kidney disease (ADPKD), little […]
Kavli Affiliate: Stefano Fusi | Authors: Li Ji-An, Fabio Stefanini, Marcus K Benna and Stefano Fusi | Summary: Synaptic plasticity is a complex phenomenon involving multiple biochemical processes that operate on different timescales. We recently showed that this complexity can greatly increase the memory capacity of neural networks when the variables that characterize the synaptic […]
Kavli Affiliate: Michael N Shadlen | Authors: NaYoung So and Michael N Shadlen | Summary: Neurons in the lateral intraparietal cortex (area LIP) represent the formation of a decision when it is linked to a specific action, such as an eye movement to a choice target. However, these neurons should be unable to represent a […]
Kavli Affiliate: Michael Shadlen | Authors: Naomi N Odean, Mehdi Sanayei and Michael N Shadlen | Summary: Abstract To form a perceptual decision the brain must acquire samples of evidence from the environment and incorporate them in computations that mediate choice behavior. While much is known about the neural circuits that process sensory information and […]