Kavli Affiliate: Changhuei Yang
| First 5 Authors: Yu Xi Huang, Simon Mahler, Maya Dickson, Aidin Abedi, Yu Tung Lo
| Summary:
Cerebral blood flow is a critical metric for cerebrovascular monitoring, with
applications in stroke detection, brain injury evaluation, aging, and
neurological disorders. Non-invasively measuring cerebral blood dynamics is
challenging due to the scalp and skull, which obstruct direct brain access and
contain their own blood dynamics that must be isolated. We developed an
aggregated seven-channel speckle contrast optical spectroscopy system to
measure blood flow and blood volume non-invasively. Each channel, with distinct
source-to-detector distance, targeted different depths to detect scalp and
brain blood dynamics separately. By briefly occluding the superficial temporal
artery, which supplies blood only to the scalp, we isolated surface blood
dynamics from brain signals. Results on 20 subjects show that scalp-sensitive
channels experienced significant reductions in blood dynamics during occlusion,
while brain-sensitive channels experienced minimal changes. This provides
experimental evidence of brain-to-scalp sensitivity in optical measurements,
highlighting optimal configuration for preferentially probing brain signals
non-invasively.
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