Spatial Transcriptomics As Rasterized Image Tensors (STARIT) characterizes cell states with subcellular molecular heterogeneity

Posted by dbos Hopkins

Kavli Affiliate: Jean Fan | Authors: Dee Velazquez, Caleb Hallinan, Roujin An, Kalen Clifton and Jean Fan | Summary: Motivation Imaging-based spatially resolved transcriptomics (imSRT) technologies provide high-throughput molecular-resolution spatial characterization of genes within cells. Conventional analysis methods to identify cell-types and states in imSRT data rely on gene count matrices derived from tallying the […]


Continue.. Spatial Transcriptomics As Rasterized Image Tensors (STARIT) characterizes cell states with subcellular molecular heterogeneity

Curving X-ray detectors for astrophysics applications

Posted by klaurent MIT

Kavli Affiliate: Marshall Bautz | Summary:Next-generation X-ray optics will revolutionize high-energy astrophysics, yet they present several challenges to design a complementary focal plane. In particular, the focal surface is curved, requiring many small, flat sensors to achieve a large field. We present work building on MIT Lincoln Laboratory technology to curve the sensor itself, improving […]


Continue.. Curving X-ray detectors for astrophysics applications

JWST Reveals a Candidate Supermassive Black Hole Binary at z=4.3 in the Brightest Sub-millimeter Galaxy in COSMOS-Web

Posted by klaurent Peking

Kavli Affiliate: Kohei Inayoshi | Summary:We present JWST/NIRSpec PRISM and G395M grating spectroscopy for AzTEC-1, a massive sub-mm bright galaxy at $z=4.34$ in the COSMOS extragalactic field. The PRISM spectrum reveals strong H$α$, a significant Balmer break, and no H$β$ detection, indicating a $100-400$ Myr-old stellar population and high dust attenuation. BPT line ratios indicate […]


Continue.. JWST Reveals a Candidate Supermassive Black Hole Binary at z=4.3 in the Brightest Sub-millimeter Galaxy in COSMOS-Web

A transition state-like acylenzyme conformation distinguishes carbapenemase activity in class A β-lactamases

Posted by dbos Hopkins

Kavli Affiliate: Michael Beer | Authors: Michael Beer, Jim Spencer and Adrian J Mulholland | Summary: Carbapenems are the most potent β-lactams, key antibiotics for healthcare-associated infections by Gram-negative bacteria and evade hydrolysis by most β-lactamases; but are increasingly threatened by emergence of enzymes exhibiting hydrolytic activity towards them. Of the four recognised β-lactamase subclasses, […]


Continue.. A transition state-like acylenzyme conformation distinguishes carbapenemase activity in class A β-lactamases

Resolving unconventional gap structure in kagome superconductors with hybrid microwave circuits

Posted by klaurent Cornell

Kavli Affiliate: Debanjan Chowdhury | Summary:Unconventional superconductivity is a hallmark of exotic quantum matter, where determining the pairing symmetry is essential for uncovering its microscopic origin. Kagome superconductors provide a fertile landscape for emergent phenomena arising from strong electronic correlations and nontrivial band topology, yet their superconducting pairing symmetry remains elusive. The superconducting gap structure […]


Continue.. Resolving unconventional gap structure in kagome superconductors with hybrid microwave circuits

Dual-polarized, mid-infrared nonreciprocal absorption

Posted by klaurent Caltech

Kavli Affiliate: Harry Atwater | Summary:The emission and absorption of thermal radiation are usually coupled via Kirchhoff’s law or reciprocity, stated as the equality of spectral directional emissivity and absorptivity. Magneto-optical materials have recently been identified as a promising route to lifting the constraint of reciprocity, with multiple experimental demonstrations using doped InAs. However, these […]


Continue.. Dual-polarized, mid-infrared nonreciprocal absorption

Private Computation Space: Experience with Trusted Multi-Cluster Federated Learning for Agriculture

Posted by klaurent Cornell

Kavli Affiliate: Abraham Stroock | Summary:Artificial Intelligence has shown to help improve agricultural practices, yet adoption remains limited: 69% of U.S. farmers have privacy concerns with sharing their data, and these concerns must be addressed before adoption is widespread. While Federated Learning has been demonstrated to protect privacy at scale for other sectors, deploying a […]


Continue.. Private Computation Space: Experience with Trusted Multi-Cluster Federated Learning for Agriculture