April 22, 2026 – Kavli Institute Pre-Print Publications

A Context-Aware Target Engagement and Pharmacodynamic Biomarker Resource to Accelerate Drug Discovery and Development

Posted by dbos April 22, 2026May 6, 2026Rockefeller

Kavli Affiliate: Li Zhao | Authors: Yuntao Yang, Li Zhao, Seyedmehdi Orouji, Ying Zhu, Rebecca L Johnson, David S Maxwell, Ioan Mica, Kaitlyn P Russell and Bissan Al-lazikani | Summary: Confirming target engagement in tumor experimental models remains a major challenge in oncology drug development. Pharmacodynamic biomarkers can help address this, but few systematic resources […]

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A recurrent neural network model of chronic pain development and recovery

Posted by dbos April 22, 2026May 6, 2026Hopkins

Kavli Affiliate: Michael Miller | Authors: Katherine Huang, Guy Marmor, Tjitse van der Molen, Zongren Zhang, Paulina Gicqueau, Javier Reveles, Kareena Morrissey, Justin Tang, Lucy Lu, Kelly Ilmi, Jacob Lue, Gabriela Barba Zuniga, Michael B. Miller, Kenneth S. Kosik, Henry Yang, Tyler Santander, Francesco Bullo and Paul K. Hansma | Summary: Chronic pain presents a […]

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Laser electro-optic frequency comb in lithium niobate nanophotonics

Posted by klaurent April 22, 2026May 6, 2026Caltech

Kavli Affiliate: Alireza Marandi | Summary:Optical frequency combs have revolutionized precision science and technology, yet their nanophotonic implementations have failed to simultaneously achieve high efficiency, power, and coherence. Optically driven microcombs provide broad and stable spectra but low usable power, whereas active comb generators, including mode-locked lasers, can be efficient yet offer less control over […]

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Anisotropic multiband magnetotransport in LaAg$_2$Ge$_2$ thin films

Posted by klaurent April 22, 2026May 6, 2026Caltech

Kavli Affiliate: Joseph Falson | Summary:ThCr$_2$Si$_2$-type intermetallics are layered conductors in which crystallographic anisotropy and multiband electronic states often give rise to characteristic magnetotransport phenomena. Here, we report the molecular-beam epitaxy growth of LaAg$_2$Ge$_2$ thin films on MgO(001) and their magnetotransport properties. The Hall effect and magnetoresistance are captured by an effective two-carrier description with […]

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Quantum Advantage for Coordinated Frequency Selection Against Distributed Jammers

Posted by klaurent April 22, 2026May 6, 2026Delft

Kavli Affiliate: Stephanie Wehner | Summary:Consider two parties who want to agree on a common frequency band for communication in the presence of independent jammers. Such jammers block a different subset of bands at each site, where each party can observe only its own set of unjammed bands. Yet, they must agree on a common […]

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Memristive Switches in Rigid Conjugated Single-Molecule Junctions

Posted by klaurent April 22, 2026May 6, 2026Delft

Kavli Affiliate: Herre Van Der Zant | Summary:Voltage-driven memristive switching has been reported in molecular junctions, yet its microscopic origin often remains elusive. Here, we study three rigid OPE-like derivatives that lack an obvious internal switching pathway using mechanically controlled break junctions (MCBJs) and observe non-volatile, bistable hysteretic IV characteristics at cryogenic temperature. We introduce […]

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Cracking Gravitational Wave Multiple Ringdown Modes in Space

Posted by klaurent April 22, 2026May 6, 2026Peking

Kavli Affiliate: Lijing Shao | Summary:Ringdown signals from perturbed black holes (BHs) offer a clean window into BH spacetime, strong-field gravity, and fundamental physics. Presently the quasi-normal modes of stellar-mass BH ringdowns have been successfully extracted in the ground-based gravitational wave (GW) observations. Looking ahead, the future space-borne observatories will listen to the ringdowns from […]

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