Kavli Affiliate: Lihong V. Wang
| First 5 Authors: Yang Zhang, Shuai Na, Jonathan J. Russin, Karteekeya Sastry, Li Lin
| Summary:
Imaging the human body’s morphological and angiographic information is
essential for diagnosing, monitoring, and treating medical conditions.
Ultrasonography performs the morphological assessment of the soft tissue based
on acoustic impedance variations, whereas photoacoustic tomography (PAT) can
visualize blood vessels based on intrinsic hemoglobin absorption.
Three-dimensional (3D) panoramic imaging of the vasculature is generally not
practical in conventional ultrasonography with limited field-of-view (FOV)
probes, and PAT does not provide sufficient scattering-based soft tissue
morphological contrast. Complementing each other, fast panoramic rotational
ultrasound tomography (RUST) and PAT are integrated for hybrid rotational
ultrasound and photoacoustic tomography (RUS-PAT), which obtains 3D ultrasound
structural and PAT angiographic images of the human body quasi-simultaneously.
The RUST functionality is achieved in a cost-effective manner using a
single-element ultrasonic transducer for ultrasound transmission and rotating
arc-shaped arrays for 3D panoramic detection. RUST is superior to conventional
ultrasonography, which either has a limited FOV with a linear array or is
high-cost with a hemispherical array that requires both transmission and
receiving. By switching the acoustic source to a light source, the system is
conveniently converted to PAT mode to acquire angiographic images in the same
region. Using RUS-PAT, we have successfully imaged the human head, breast,
hand, and foot with a 10 cm diameter FOV, submillimeter isotropic resolution,
and 10 s imaging time for each modality. The 3D RUS-PAT is a powerful tool for
high-speed, 3D, dual-contrast imaging of the human body with potential for
rapid clinical translation.
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