Kavli Affiliate: Jing Wang
| First 5 Authors: Alexander D. Kaiser, Jing Wang, Aaron L. Brown, Enbo Zhu, Tzung Hsiai
| Summary:
The zebrafish is a valuable model organism for studying cardiac development
and diseases due to its many shared aspects of genetics and anatomy with humans
and ease of experimental manipulations. Computational fluid-structure
interaction (FSI) simulations are an efficient and highly controllable means to
study the function of cardiac valves in development and diseases. Due to their
small scales, little is known about the mechanical properties of zebrafish
cardiac valves, limiting existing computational studies of zebrafish valves and
their interaction with blood. To circumvent these limitations, we took a
largely first-principles approach called design-based elasticity that allows us
to derive valve geometry, fiber orientation and material properties. In FSI
simulations of an adult zebrafish aortic valve, these models produce realistic
flow rates when driven by physiological pressures and demonstrate the
spatiotemporal dynamics of valvular mechanical properties. These models can be
used for future studies of zebrafish cardiac hemodynamics, development, and
disease.
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