A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in a glutamatergic spine reveals dynamics of kinase activation in the first several seconds after a complex synaptic stimulus.

Posted by dbos UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B Kennedy | Summary: Long-term potentiation (LTP) is a biochemical process in excitatory glutamatergic synapses in the Central Nervous System (CNS). It is initiated by a bout of synaptic activation that is strong enough to contribute to […]


Continue.. A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in a glutamatergic spine reveals dynamics of kinase activation in the first several seconds after a complex synaptic stimulus.

The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice

Posted by dbos Hopkins

Kavli Affiliate: Vikram Chib | Authors: Grace E Steward and Vikram S Chib | Summary: Feelings of cognitive fatigue emerge through repeated mental exertion and are ubiquitous in our daily lives. However, there is a limited understanding of the neurobiological mechanisms underlying the influence of cognitive fatigue on decisions to exert. We use functional magnetic […]


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Resistance to age-related hearing loss in the echolocating big brown bat (Eptesicus fuscus)

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Bryan Zhou, André Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West-Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu, Jude M. Phillip, Won Jin Ho, David E. Sanin and Denis Wirtz | Summary: Enrichment of […]


Continue.. Resistance to age-related hearing loss in the echolocating big brown bat (Eptesicus fuscus)

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Bryan Zhou, André Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West-Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu, Jude M. Phillip, Won Jin Ho, David E. Sanin and Denis Wirtz | Summary: Enrichment of […]


Continue.. High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

Sst- and Vip-Cre mouse lines without age-related hearing loss

Posted by dbos UCSF

Kavli Affiliate: Andrea Hasenstaub | Authors: Calvin T Foss, Timothy Olsen, James Bigelow and Andrea R Hasenstaub | Summary: GABAergic interneurons, including somatostatin (SST) and vasoactive intestinal peptide (VIP) positive cells, play a crucial role in cortical circuit processing. Cre recombinase-mediated manipulation of these interneurons is facilitated by commercially available knock-in mouse strains such as […]


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Analysis of the full Spitzer microlensing sample I: Dark remnant candidates and Gaia predictions

Posted by dbos MIT

Kavli Affiliate: Michael M. Fausnaugh | First 5 Authors: Krzysztof A. Rybicki, Yossi Shvartzvald, Jennifer C. Yee, Sebastiano Calchi Novati, Eran O. Ofek | Summary: In the pursuit of understanding the population of stellar remnants within the Milky Way, we analyze the sample of $sim 950$ microlensing events observed by the Spitzer Space Telescope between […]


Continue.. Analysis of the full Spitzer microlensing sample I: Dark remnant candidates and Gaia predictions

Research on Tibetan Tourism Viewpoints information generation system based on LLM

Posted by dbos Peking

Kavli Affiliate: Ke Wang | First 5 Authors: Jinhu Qi, Shuai Yan, Wentao Zhang, Yibo Zhang, Zirui Liu | Summary: Tibet, ensconced within China’s territorial expanse, is distinguished by its labyrinthine and heterogeneous topography, a testament to its profound historical heritage, and the cradle of a unique religious ethos. The very essence of these attributes, […]


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Approach for composition measurement of cosmic rays using the muon-to-electron ratio observed by LHAASO-KM2A

Posted by dbos Peking

Kavli Affiliate: Zhuo Li | First 5 Authors: Xishui Tian, Zhuo Li, Quanbu Gou, Hengying Zhang, Huihai He | Summary: Composition measurement of cosmic rays (CRs) around the knee of the CR energy spectrum is crucial for studying the processes of particle acceleration and propagation of Galactic CRs. The Square Kilometer Array (KM2A) of Large […]


Continue.. Approach for composition measurement of cosmic rays using the muon-to-electron ratio observed by LHAASO-KM2A

Multiobjective Vehicle Routing Optimization with Time Windows: A Hybrid Approach Using Deep Reinforcement Learning and NSGA-II

Posted by dbos Peking

Kavli Affiliate: Ran Wang | First 5 Authors: Rixin Wu, Ran Wang, Jie Hao, Qiang Wu, Ping Wang | Summary: This paper proposes a weight-aware deep reinforcement learning (WADRL) approach designed to address the multiobjective vehicle routing problem with time windows (MOVRPTW), aiming to use a single deep reinforcement learning (DRL) model to solve the […]


Continue.. Multiobjective Vehicle Routing Optimization with Time Windows: A Hybrid Approach Using Deep Reinforcement Learning and NSGA-II

Forecasting Supernova Observations with the CSST: I. Photometric Samples

Posted by dbos Peking

Kavli Affiliate: Hu Zhan | First 5 Authors: Chengqi Liu, Youhua Xu, Xianmin Meng, Xin Zhang, Shi-Yu Li | Summary: The China Space Station Telescope (CSST, also known as Xuntian) is a serviceable two-meter-aperture wide-field telescope operating in the same orbit as the China Space Station. The CSST plans to survey a sky area of […]


Continue.. Forecasting Supernova Observations with the CSST: I. Photometric Samples