Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation

Posted by dbos Columbia

Kavli Affiliate: Franck Polleux | Authors: Carlos Diaz-Salazar, Marine A KRZISCH, Juyoun Yoo, Patricia Nano, Aparna Bhaduri, Rudolph Jaenisch and Franck Polleux | Summary: Microglia play key roles in shaping synaptic connectivity during neural circuits development. Whether microglia display human-specific features of structural and functional maturation is currently unknown. We show that the ancestral gene […]


Continue.. Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation

Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Gannon A. McDonough, Yuchen Cheng, Katherine Morillo, Ryan N. Doan, Connor J. Kenny, Aaron Foutz, Chae Kim, Mark L. Cohen, Brian S. Appleby, Christopher A. Walsh, Jiri G. Safar, August Yue Huang and Michael B. Miller | Summary: Creutzfeldt-Jakob Disease (CJD), the most common human prion disease, is associated […]


Continue.. Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

Unifying community-wide whole-brain imaging datasets enables robust automated neuron identification and reveals determinants of neuron positioning in C. elegans

Posted by dbos UCSF

Kavli Affiliate: Saul Kato | Authors: Daniel Yutaka Sprague, Kevin Rusch, Raymond L Dunn, Jackson Borchardt, Greg Bubnis, Grace Chiu, Chentao Wen, Ryoga Suzuki, Shivesh Chaudhary, Ben Dichter, Ryan Ly, Shuichi Onami, Hang Lu, Kotaro Kimura, Eviatar I Yemini and Saul Kato | Summary: We develop a data harmonization approach for C. elegans volumetric microscopy […]


Continue.. Unifying community-wide whole-brain imaging datasets enables robust automated neuron identification and reveals determinants of neuron positioning in C. elegans