Mapping energy landscapes of homopolymeric RNAs via simulated tempering and deep unsupervised learning

Posted by dbos UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Vysakh Ramachandran and Davit A Potoyan | Summary: Conformational dynamics plays crucial roles in RNA functions about sensing and responding to environmental signals. The liquid-liquid phase separation of RNAs and the formation of stress granules partly relies on RNA’s conformational plasticity and its ability to engage in multivalent […]


Continue.. Mapping energy landscapes of homopolymeric RNAs via simulated tempering and deep unsupervised learning

Substructure of the brain’s Cingulo-Opercular network

Posted by dbos UCSD / Salk

Kavli Affiliate: Deanna J. Greene | Authors: Carolina Badke D’Andrea, Timoth O Laumann, Dillan J Newbold, Steven M Nelson, Ashley N Nielsen, Roselyne Chauvin, Scott Marek, Deanna J. Greene, Nico U F Dosenbach and Evan M Gordon | Summary: HThe Cingulo-Opercular network (CON) is an executive network of the human brain that regulates actions. CON […]


Continue.. Substructure of the brain’s Cingulo-Opercular network

Phosphoglycerate kinase 1 is a central leverage point in Parkinson’s disease driven neuronal metabolic deficits

Posted by dbos Rockefeller, Yale

Kavli Affiliate: Timothy A. Ryan & Pietro De Camilli | Authors: Talex Kokotos, Aldana Antoniazzi, Santiago Unda, Myung Soo Kokotos, Daehun Park, David Eliezer, Michael Kaplitt, Pietro De Camilli and Timothy Ryan | Summary: Phosphoglycerate kinase 1 (PGK1), the first ATP producing glycolytic enzyme, has emerged as a therapeutic target for Parkinson’s Disease (PD), since […]


Continue.. Phosphoglycerate kinase 1 is a central leverage point in Parkinson’s disease driven neuronal metabolic deficits

Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting

Posted by dbos UCSF

Kavli Affiliate: Xin Duan | Authors: Axel Guskjolen, Jagroop Dhaliwal, Juan de la Parra, Jonathan R Epp, Sangyoon Ko, Erin Chahley, Mitch de Snoo, Michela Solari, Prabdeep Panesar, Jason Scott Snyder, Xin Duan, Joshua Sanes, Sheena Josselyn and Paul Frankland | Summary: Post-training increases in hippocampal neurogenesis are associated with forgetting of hippocampus-dependent memories in […]


Continue.. Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting

Developmental origin and local signals cooperate to determine septal astrocyte identity

Posted by dbos UCSF

Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Yajun Xie, Christopher M Reid, Alejandro A Granados, Miguel Turrero Garcia, Fiona Dale-Huang, Sarah M Hanson, Walter R Mancia Leon, Jonathan Liu, Manal A Adam, Olivia Mosto, Angela Oliveira Pisco, Arturo Alvarez-Buylla and Corey C Harwell | Summary: Astrocyte specification during development is influenced by both intrinsic and extrinsic […]


Continue.. Developmental origin and local signals cooperate to determine septal astrocyte identity

Discovery of a variable energy-dependent X-ray polarization in the accreting neutron star GX 5-1

Posted by dbos MIT

Kavli Affiliate: Herman L. Marshall | First 5 Authors: Sergio Fabiani, Fiamma Capitanio, Rosario Iaria, Juri Poutanen, Andrea Gnarini | Summary: We report on the coordinated observations of the neutron star low-mass X-ray binary (NS-LMXB) gx in X-rays (IXPE, NICER, Nustar and INTEGRAL), optical (REM and LCO), near-infrared (REM), mid-infrared (VLT VISIR), and radio (ATCA). […]


Continue.. Discovery of a variable energy-dependent X-ray polarization in the accreting neutron star GX 5-1

Pi-DUAL: Using Privileged Information to Distinguish Clean from Noisy Labels

Posted by dbos Peking

Kavli Affiliate: Ke Wang | First 5 Authors: Ke Wang, Guillermo Ortiz-Jimenez, Rodolphe Jenatton, Mark Collier, Efi Kokiopoulou | Summary: Label noise is a pervasive problem in deep learning that often compromises the generalization performance of trained models. Recently, leveraging privileged information (PI) — information available only during training but not at test time — […]


Continue.. Pi-DUAL: Using Privileged Information to Distinguish Clean from Noisy Labels

Pi-DUAL: Using Privileged Information to Distinguish Clean from Noisy Labels

Posted by dbos Peking

Kavli Affiliate: Ke Wang | First 5 Authors: Ke Wang, Guillermo Ortiz-Jimenez, Rodolphe Jenatton, Mark Collier, Efi Kokiopoulou | Summary: Label noise is a pervasive problem in deep learning that often compromises the generalization performance of trained models. Recently, leveraging privileged information (PI) — information available only during training but not at test time — […]


Continue.. Pi-DUAL: Using Privileged Information to Distinguish Clean from Noisy Labels

Measurement of branching fractions and direct $CP$ asymmetries for $B to Kπ$ and $Btoππ$ decays at Belle II

Posted by dbos Tokyo

Kavli Affiliate: T. Higuchi | First 5 Authors: Belle II Collaboration, I. Adachi, L. Aggarwal, H. Ahmed, H. Aihara | Summary: We report measurements of the branching fractions and direct $it{CP}$ asymmetries of the decays $B^0 to K^+ pi^-$, $B^+ to K^+ pi^0$, $B^+ to K^0 pi^+$, and $B^0 to K^0 pi^0$, and use these […]


Continue.. Measurement of branching fractions and direct $CP$ asymmetries for $B to Kπ$ and $Btoππ$ decays at Belle II

Measurement of branching fractions and direct $CP$ asymmetries for $B to Kπ$ and $Btoππ$ decays at Belle II

Posted by dbos Tokyo

Kavli Affiliate: T. Higuchi | First 5 Authors: Belle II Collaboration, I. Adachi, L. Aggarwal, H. Ahmed, H. Aihara | Summary: We report measurements of the branching fractions and direct $it{CP}$ asymmetries of the decays $B^0 to K^+ pi^-$, $B^+ to K^+ pi^0$, $B^+ to K^0 pi^+$, and $B^0 to K^0 pi^0$, and use these […]


Continue.. Measurement of branching fractions and direct $CP$ asymmetries for $B to Kπ$ and $Btoππ$ decays at Belle II