Kavli Affiliate: Changhuei Yang
| First 5 Authors: Yu Xi Huang, Simon Mahler, Jerome Mertz, Changhuei Yang,
| Summary:
Diffusing wave spectroscopy (DWS) is a group of techniques used to measure
the dynamics of a scattering medium in a non-invasive manner. DWS methods rely
on detecting the speckle light field from the moving scattering media and
measuring the speckle decorrelation time to quantify the scattering mediums
dynamics. For DWS, the signal-to-noise (SNR) is determined by the ratio between
measured decorrelation time to the standard error of the measurement. This SNR
is often low in certain applications because of high noise variances and low
signal intensity, especially in biological applications with restricted
exposure and emission levels. To address this photon-limited signal-to-noise
ratio problem, we investigated, theoretically and experimentally, the SNR of an
interferometric speckle visibility spectroscopy (iSVS) compared to more
traditional DWS methods. We found that iSVS can provide excellent SNR
performance through its ability to overcome camera noise. We also proved iSVS
system has more relaxed constraints on the reference beam properties than most
other interferometric systems. For an iSVS to function properly, we simply
require the reference beam to exhibit local temporal stability, while incident
angle, reference phase, and intensity uniformity do not need to be constrained.
This flexibility can potentially enable more unconventional iSVS implementation
schemes.
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