Prioritizing virtual screening with interpretable interaction fingerprints

Kavli Affiliate: Michael Keiser | Authors: Alexandre V Fassio, Laura Shub, Luca Ponzoni, Jessica McKinley, Matthew J O’Meara, Rafaela S Ferreira, Michael J Keiser and Raquel C de Melo Minardi | Summary: Machine learning-based drug discovery success depends on molecular representation. Yet traditional molecular fingerprints omit both the protein and pointers back to structural information […]


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A developmental pathway for epithelial-to-motoneuron transformation in C. elegans

Kavli Affiliate: Shai Shaham | Authors: Alina Rashid, Maya Tevlin, Yun Lu and Shai Shaham | Summary: Motoneurons and motoneuron-like pancreatic beta cells arise from radial glia and ductal cells, both tube-lining progenitors that share molecular regulators. To uncover programs underlying motoneuron formation, we studied a similar, cell-division-independent transformation of the C. elegans tube-lining Y […]


Continue.. A developmental pathway for epithelial-to-motoneuron transformation in C. elegans

A Character-Level Length-Control Algorithm for Non-Autoregressive Sentence Summarization

Kavli Affiliate: Xiang Zhang | First 5 Authors: Puyuan Liu, Xiang Zhang, Lili Mou, , | Summary: Sentence summarization aims at compressing a long sentence into a short one that keeps the main gist, and has extensive real-world applications such as headline generation. In previous work, researchers have developed various approaches to improve the ROUGE […]


Continue.. A Character-Level Length-Control Algorithm for Non-Autoregressive Sentence Summarization

A Character-Level Length-Control Algorithm for Non-Autoregressive Sentence Summarization

Kavli Affiliate: Xiang Zhang | First 5 Authors: Puyuan Liu, Xiang Zhang, Lili Mou, , | Summary: Sentence summarization aims at compressing a long sentence into a short one that keeps the main gist, and has extensive real-world applications such as headline generation. In previous work, researchers have developed various approaches to improve the ROUGE […]


Continue.. A Character-Level Length-Control Algorithm for Non-Autoregressive Sentence Summarization

Unifying model for three forms of contextual modulation including feedback input from higher visual areas

Kavli Affiliate: Kenneth Miller | Authors: Serena Di santo, Mario Dipoppa, Andreas Keller, Morgane Roth, Massimo Scanziani and Kenneth D Miller | Summary: Neural responses to a localized visual stimulus are modulated by the content of its surrounding. This phenomenon manifests in several forms of contextual modulation, including three interrelated properties of the visual cortex: […]


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Divide to Adapt: Mitigating Confirmation Bias for Domain Adaptation of Black-Box Predictors

Kavli Affiliate: Zheng Zhu | First 5 Authors: Jianfei Yang, Xiangyu Peng, Kai Wang, Zheng Zhu, Jiashi Feng | Summary: Domain Adaptation of Black-box Predictors (DABP) aims to learn a model on an unlabeled target domain supervised by a black-box predictor trained on a source domain. It does not require access to both the source-domain […]


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Lesion classification by model-based feature extraction: A differential affine invariant model of soft tissue elasticity

Kavli Affiliate: Jing Wang | First 5 Authors: Weiguo Cao, Marc J. Pomeroy, Zhengrong Liang, Yongfeng Gao, Yongyi Shi | Summary: The elasticity of soft tissues has been widely considered as a characteristic property to differentiate between healthy and vicious tissues and, therefore, motivated several elasticity imaging modalities, such as Ultrasound Elastography, Magnetic Resonance Elastography, […]


Continue.. Lesion classification by model-based feature extraction: A differential affine invariant model of soft tissue elasticity

On Consistency in Graph Neural Network Interpretation

Kavli Affiliate: Xiang Zhang | First 5 Authors: Tianxiang Zhao, Dongsheng Luo, Xiang Zhang, Suhang Wang, | Summary: Uncovering rationales behind predictions of graph neural networks (GNNs) has received increasing attention over recent years. Instance-level GNN explanation aims to discover critical input elements, like nodes or edges, that the target GNN relies upon for making […]


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A Model Predictive Control Functional Continuous Time Bayesian Network for Self-Management of Multiple Chronic Conditions

Kavli Affiliate: Jing Wang | First 5 Authors: Syed Hasib Akhter Faruqui, Adel Alaeddini, Jing Wang, Susan P Fisher-Hoch, Joseph B Mccormick | Summary: Multiple chronic conditions (MCC) are one of the biggest challenges of modern times. The evolution of MCC follows a complex stochastic process that is influenced by a variety of risk factors, […]


Continue.. A Model Predictive Control Functional Continuous Time Bayesian Network for Self-Management of Multiple Chronic Conditions