Kavli Affiliate: M. Gharib
| First 5 Authors: E. F. Schibber, D. R. Mittelstein, M. Gharib, M. G. Shapiro, P. P. Lee
| Summary:
The method of oncotripsy, first proposed in [S. Heyden and M. Ortiz (2016).
Oncotripsy: Targeting cancer cells selectively via resonant harmonic
excitation. Journal of the Mechanics and Physics of Solids, 92:164-175],
exploits aberrations in the material properties and morphology of cancerous
cells in order to ablate them selectively by means of tuned low-intensity
pulsed ultrasound (LIPUS). We propose a dynamical model of oncotripsy that
follows as an application of cell dynamics, statistical mechanical theory of
network elasticity and ‘birth-death’ kinetics to describe processes of damage
and repair of the cytoskeleton. We also develop a reduced dynamical model that
approximates the three-dimensional dynamics of the cell and facilitates
parametric studies, including sensitivity analysis and process optimization. We
show that the dynamical model predicts—and provides a conceptual basis for
understanding—the oncotripsy effect and other trends in the data of [D. R.
Mittelstein, J. Ye, E. F. Schibber, A. Roychoudhury, L. T. Martinez, M. H.
Fekrazad, M. Ortiz, P. P. Lee, M. G. Shapiro, M. Gharib (2019). Selective
Ablation of Cancer Cells with Low Intensity Pulsed Ultrasound. BioRxiv] for
cells in suspension, including the dependence of cell-death curves on cell and
process parameters.
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