Harnessing Avidity: Quantifying Entropic and Energetic Effects of Linker Length and Rigidity Required for Multivalent Binding of Antibodies to HIV-1 Spikes

Posted by klaurent Caltech

Kavli Affiliate: Pamela J. Bjorkman | First 5 Authors: Tal Einav, Shahrzad Yazdi, Aaron Coey, Pamela J. Bjorkman, Rob Phillips | Summary: Due to the low density of envelope (Env) spikes on the surface of HIV-1, neutralizing IgG antibodies rarely bind bivalently using both antigen-binding arms (Fabs) to crosslink between spikes (inter-spike crosslinking), instead resorting […]


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