Open-source Photobleacher for Fluorescent Imaging of Large Pigment-Rich Tissues

Kavli Affiliate: Nathaniel Heintz | Authors: Tatsuya C. Murakami, Nick Belenko, Griffin Dennis, Cuidong Wang, Maria Esterlita Siantoputri, Yurie Maeda, Christina Pressl and Nathaniel Heintz | Summary: Fluorescent imaging enables visualization of the specific molecules of interest with high contrast, and the use of multiple fluorophores in a single tissue sample allows visualization of complex […]


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TUCL-Seq for miRNA single molecule sequencing

Kavli Affiliate: Li Zhao | Authors: Jicai Fan, Zhao Li, Xuejiao You, Lei Liu, Huan Jin, Ping Wu, Yushan Han, Lei Sun, Pengwei Xu, Yongfeng Liu, Jianjun Luo and Qin Yan | Summary: MicroRNAs (miRNAs) are pivotal regulatory molecules in gene expression, and their precise quantification is essential for elucidating their roles in diverse biological […]


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MACER3D — an upgrade of MACER2D with enhanced subgrid models and gas physics — and its application to simulating AGN feedback in a massive elliptical galaxy

Kavli Affiliate: Feng Yuan | First 5 Authors: Haoen Zhang, Haojie Xia, Suoqing Ji, Feng Yuan, Minhang Guo | Summary: We present MACER3D (Multiscale AGN-regulated Cosmic Ecosystem Resolver in 3D), a new suite of three-dimensional hydrodynamic simulations that study active galactic nuclei (AGN) feedback on galactic scales over Gyr duration, with major enhancement in subgrid […]


Continue.. MACER3D — an upgrade of MACER2D with enhanced subgrid models and gas physics — and its application to simulating AGN feedback in a massive elliptical galaxy

Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Kavli Affiliate: Kevin Bender | Authors: Hao Wu, Luqun Shen, Jonathan Indajang, Neil K Savalia, Timothy G Johnson, Jiayin Qu, Kevin J Bender and Alex C Kwan | Summary: SCN2A is a high-confidence risk gene for autism spectrum disorder. Loss-of-function mutations in Scn2a reduce dendritic excitability in neocortical pyramidal cells. However, the impact of Scn2a […]


Continue.. Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

ViralQC: A Tool for Assessing Completeness and Contamination of Predicted Viral Contigs

Kavli Affiliate: Cheng Peng | First 5 Authors: Cheng Peng, Jiayu Shang, Jiaojiao Guan, Yanni Sun, | Summary: Motivation: Viruses represent the most abundant biological entities on the planet and play vital roles in diverse ecosystems. Cataloging viruses across various environments is essential for understanding their properties and functions. Metagenomic sequencing has emerged as the […]


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High-efficiency broadband active metasurfaces via reversible metal electrodeposition

Kavli Affiliate: Xuebing Wu | Summary:Realizing active metasurfaces with substantial tunability is important for many applications but remains challenging due to difficulties in dynamically tuning light-matter interactions at subwavelength scales. Here, we introduce reversible metal electrodeposition as a versatile approach for enabling active metasurfaces with exceptional tunability across a broad bandwidth. As a proof of […]


Continue.. High-efficiency broadband active metasurfaces via reversible metal electrodeposition