Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction

Kavli Affiliate: Yifan Cheng | Authors: Junrui Li, Yifei chen, Shawn Zheng, Angus McDonald, John W. Sedat, David A. Agard and Yifan Cheng | Summary: With technological advancements in recent years, single particle cryogenic electron microscopy (cryo-EM) has become a major methodology for structural biology. Structure determination by single particle cryo-EM is premised on randomly […]


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Population Representation of the Confidence in a Decision in the Parietal Cortex

Kavli Affiliate: Michael Shadlen | Authors: Ariel Zylberberg and Michael N Shadlen | Summary: Confidence in a decision is the belief, prior to feedback, that one’s choice is correct. In the brain, many decisions are implemented as a race between competing evidence-accumulation processes. We ask whether the neurons that represent evidence accumulation also carry information […]


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Psychometric-Based Evaluation for Theorem Proving with Large Language Models

Kavli Affiliate: Long Zhang | First 5 Authors: Jianyu Zhang, Yongwang Zhao, Long Zhang, Jilin Hu, Xiaokun Luan | Summary: Large language models (LLMs) for formal theorem proving have become a prominent research focus. At present, the proving ability of these LLMs is mainly evaluated through proof pass rates on datasets such as miniF2F. However, […]


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LEAD: Large Foundation Model for EEG-Based Alzheimer’s Disease Detection

Kavli Affiliate: Xiang Zhang | First 5 Authors: Yihe Wang, Nan Huang, Nadia Mammone, Marco Cecchi, Xiang Zhang | Summary: Electroencephalogram (EEG) provides a non-invasive, highly accessible, and cost-effective solution for Alzheimer’s Disease (AD) detection. However, existing methods, whether based on manual feature extraction or deep learning, face two major challenges: the lack of large-scale […]


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