Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile

Kavli Affiliate: Michael Miller | Authors: Sonya Kumar Bharathkar, Michael J. Miller and Beth M. Stadtmueller | Summary: Secretory (S) Immunoglobin (Ig) A is the predominant mucosal antibody, which mediates host interactions with commensal and pathogenic microbes, including Clostridioides difficile. SIgA adopts a polymeric IgA structure that is bound by secretory component (SC). Despite significance, […]


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The Speed of Sound in Methane under Conditions of the Thermal Boundary Layer of Uranus

Kavli Affiliate: Peter Graham | First 5 Authors: Thomas G. White, Hannah Poole, Emma E. McBride, Matthew Oliver, Adrien Descamps | Summary: We present the first direct observations of acoustic waves in warm dense matter. We analyze wavenumber- and energy-resolved X-ray spectra taken from warm dense methane created by laser-heating a cryogenic liquid jet. X-ray […]


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The life cycle of stars and their planets from the high energy perspective

Kavli Affiliate: David A. Principe | First 5 Authors: Lia Corrales, Keivan G. Stassun, Tim Cunningham, Girish Duvvuri, Jeremy J. Drake | Summary: One of the key research themes identified by the Astro2020 decadal survey is Worlds and Suns in Context. The Advanced X-ray Imaging Satellite (AXIS) is a proposed NASA APEX mission that will […]


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Prospects for Time-Domain and Multi-Messenger Science with AXIS

Kavli Affiliate: Erin Kara | First 5 Authors: The AXIS Time-Domain, Multi-Messenger Science Working Group, :, Riccardo Arcodia, Franz E. Bauer | Summary: The Advanced X-ray Imaging Satellite (AXIS) promises revolutionary science in the X-ray and multi-messenger time domain. AXIS will leverage excellent spatial resolution (<1.5 arcsec), sensitivity (80x that of Swift), and a large […]


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Constraints on Dark Matter from Dynamical Heating of Stars in Ultrafaint Dwarfs. Part 1: MACHOs and Primordial Black Holes

Kavli Affiliate: Peter W. Graham | First 5 Authors: Peter W. Graham, Harikrishnan Ramani, , , | Summary: We place limits on dark matter made up of compact objects significantly heavier than a solar mass, such as MACHOs or primordial black holes (PBHs). In galaxies, the gas of such objects is generally hotter than the […]


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Black holes regulate cold gas accretion in massive galaxies

Kavli Affiliate: Luis C. Ho | First 5 Authors: Tao Wang, Ke Xu, Yuxuan Wu, Yong Shi, David Elbaz | Summary: Nearly every massive galaxy contains a supermassive black hole (BH) at its center. For decades, both theory and numerical simulations have indicated that BHs play a central role in regulating the growth and quenching […]


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Coherent Self-Interactions of Dark Matter in the Bullet Cluster

Kavli Affiliate: Peter W. Graham | First 5 Authors: Zachary Bogorad, Peter W. Graham, Harikrishnan Ramani, , | Summary: Many models of dark matter include self-interactions beyond gravity. A variety of astrophysical observations have previously been used to place limits on the strength of such self-interactions. However, previous works have generally focused either on short-range […]


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An encyclopedia of enhancer-gene regulatory interactions in the human genome

Kavli Affiliate: Michael Beer | Authors: Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, Maya U. Sheth, Kushal K. Dey, Evelyn Jagoda, Ramil N. Nurtdinov, Wang Xi, Anthony S. Tan, Hank Jones, X. Rosa Ma, David Yao, Joseph Nasser, Ziga Avsec, Benjamin T. James, Muhammad S. Shamim, Neva C. Durand, Suhas S. P. Rao, Ragini […]


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Investigating egocentric tuning in hippocampal CA1 neurons using simulated data

Kavli Affiliate: Edvard Moser & May-Britt Moser | Authors: Jordan Carpenter, Jan Sigurd Blackstad, David Tingley, Valentin A. Normand, Edvard I. Moser, May-Britt Moser and Benjamin A. Dunn | Summary: Navigation requires integrating sensory information with a stable schema to create a dynamic map of an animal’s position using egocentric and allocentric coordinate systems. In […]


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Microbiota-dependent early life programming of gastrointestinal motility

Kavli Affiliate: David Linden | Authors: Mary E Frith, Purna C Kashyap, David R Linden, Betty Theriault and Eugene B Chang | Summary: Gastrointestinal microbes modulate peristalsis and stimulate the enteric nervous system (ENS), whose development, as in the central nervous system (CNS), continues into the murine postweaning period. Given that adult CNS function depends […]


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