Kavli Affiliate: Daniel J. Needleman | First 5 Authors: Colm P Kelleher, Yash Rana, Daniel J Needleman, , | Summary: During eukaryotic cell division, a microtubule-based structure called the spindle exerts forces on chromosomes, thereby organizing and segregating them Extensive work demonstrates that the forces acting parallel to the spindle axis, including those responsible for […]
Kavli Affiliate: Francis J. Doyle | First 5 Authors: Dinesh Krishnamoorthy, Francis J. Doyle III, , , | Summary: This work considers the problem of personalized dose guidance using Bayesian optimization that learns the optimum drug dose tailored to each individual, thus improving therapeutic outcomes. Safe learning using interior point method ensures patient safety with […]
Kavli Affiliate: Vinothan N. Manoharan | First 5 Authors: Clary Rodriguez-Cruz, Mehdi Molaei, Amruthesh Thirumalaiswamy, Klebert Feitosa, Vinothan N. Manoharan | Summary: Many soft and biological materials display so-called ‘soft glassy’ dynamics; their constituents undergo anomalous random motion and intermittent cooperative rearrangements. Stock prices show qualitatively similar dynamics, whose origins also remain poorly understood. Recent […]
Kavli Affiliate: Vinothan N. Manoharan | First 5 Authors: Clary Rodriguez-Cruz, Mehdi Molaei, Amruthesh Thirumalaiswamy, Klebert Feitosa, Vinothan N. Manoharan | Summary: Many soft and biological materials display so-called ‘soft glassy’ dynamics; their constituents undergo anomalous random motions and complex cooperative rearrangements. A recent simulation model of one soft glassy material, a coarsening foam, suggested […]
Kavli Affiliate: Daniel J. Needleman | First 5 Authors: Bezia Lemma, Linnea Lemma, Stephanie C. Ems-McClung, Claire E. Walczak, Zvonimir Dogic | Summary: Connecting the large-scale emergent behaviors of active materials to the microscopic properties of their constituents is a challenge due to a lack of data on the multiscale dynamics and structure of such […]
Kavli Affiliate: Ariel Amir | First 5 Authors: Ori Hachmo, Ariel Amir, , , | Summary: Transcription Factors (TFs) are proteins that regulate gene expression. The regulation mechanism is via the binding of a TF to a specific part of the gene associated with it, the TF’s target. The target of a specific TF corresponds […]
Kavli Affiliate: L. Mahadevan | First 5 Authors: Fabio Giardina, S Ganga Prasath, L Mahadevan, , | Summary: Cooperative task execution, a hallmark of eusociality, is enabled by local interactions between the agents and the environment through a dynamically evolving communication signal. Inspired by the collective behavior of social insects whose dynamics is modulated by […]
Kavli Affiliate: Vinothan N. Manoharan | First 5 Authors: Anna B. Stephenson, Ming Xiao, Victoria Hwang, Liangliang Qu, Paul A. Odorisio | Summary: Photonic balls are spheres tens of micrometers in diameter containing assemblies of nanoparticles or nanopores with a spacing comparable to the wavelength of light. When these nanoscale features are disordered, but still […]
Kavli Affiliate: L. Mahadevan | First 5 Authors: Levi H. Dudte, Gary P. T. Choi, Kaitlyn P. Becker, L. Mahadevan, | Summary: We present an additive approach for the inverse design of kirigami-based mechanical metamaterials by focusing on the design of the negative spaces instead of the kirigami tiles. By considering each negative space as […]
Kavli Affiliate: L. Mahadevan | First 5 Authors: Levi H. Dudte, Gary P. T. Choi, Kaitlyn P. Becker, L. Mahadevan, | Summary: We present an additive approach for the inverse design of kirigami-based mechanical metamaterials by focusing on the empty (negative) spaces instead of the solid tiles. By considering each negative space as a four-bar […]