Simultaneous multi-site editing of individual genomes using retron arrays

Kavli Affiliate: Seth Shipman | Authors: Alejandro Gonzalez-Delgado, Santiago C Lopez, Matias Rojas-Montero, Chloe B Fishman and Seth L Shipman | Summary: Our understanding of genomics is limited by the scale of our genomic technologies. While libraries of genomic manipulations scaffolded on CRISPR gRNAs have been transformative, these existing approaches are typically multiplexed across genomes. […]


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SIMPLE: Simple Intensity Map Producer for Line Emission

Kavli Affiliate: Eiichiro Komatsu | Summary:We present the Simple Intensity Map Producer for Line Emission (SIMPLE), a public code for quickly simulating mock line-intensity maps, and an analytical framework for modeling intensity maps including observational effects. SIMPLE can be applied to any spectral line sourced by galaxies. The SIMPLE code is based on lognormal mock […]


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Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Kavli Affiliate: Seth Blackshaw | Authors: Cheng Qian, Ying Xin, Cheng Qi, Hui Wang, Bryan C. Dong, Donald Zack, Seth Blackshaw, Samer Hattar, Feng-Quan Zhou and Jiang Qian | Summary: The progressive death of mature neurons often results in neurodegenerative diseases. While the previous studies have mostly focused on identifying intrinsic mechanisms controlling neuronal survival, […]


Continue.. Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells