Multiplexed and scalable cellular phenotyping toward the standardized three-dimensional human neuroanatomy

Posted by klaurent Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Tatsuya C. Murakami and Nathaniel Heintz | Summary: Abstract The advent of three-dimensional histological methods has advanced studies of cellular-resolution anatomy of the brain. The use of whole-mount staining and tissue clearing has advanced systems-level identification of cells underlying brain functions in mouse models. However, application of these methods […]


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Copiotrophs dominate rhizosphere microbiomes and growth rate potential is a major factor explaining the rhizosphere effect

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jose Suarez Lopez | Authors: José Luis López, Nikolaos Pappas, Sanne WM Poppeliers, Juan J. Sanchez-Gil, Arista Fourie-Fouche, Ronnie de Jonge and Bas E. Dutilh | Summary: Abstract The structure and function of the root microbial community is shaped by plant root activity, enriching specific microbial taxa and functions from the surrounding soil […]


Continue.. Copiotrophs dominate rhizosphere microbiomes and growth rate potential is a major factor explaining the rhizosphere effect

Multiplexed selectivity screening of anti-GPCR antibodies

Posted by klaurent Rockefeller

Kavli Affiliate: Thomas P. Sakmar | Authors: Leo Dahl, Ilana Kotliar, Annika Bendes, Tea Dodig-Crnkovic, Samuel Fromm, Arne Elofsson, Mathias Uhlen, Thomas P Sakmar and Jochen Schwenk | Summary: Abstract G protein-coupled receptors (GPCRs) control critical cellular signaling pathways. Therapeutic agents, such as antibodies (Abs), are being developed to modulate GPCR signaling pathways. However, validating […]


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