Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

Kavli Affiliate: Peter Walter | Authors: Rochelle Coulson, Valentina Frattini, Caitlin Moyer, Jennifer Hodges, Peter Walter, Philippe Mourrain, Yi Zuo and Gordon Wang | Summary: Fragile X syndrome (FXS) is caused by the functional loss of Fragile X messenger ribonucleoprotein (FMRP), a translational regulator that binds the transcripts of many proteins involved in synaptic function […]


Continue.. Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

Ambiguity, Invisibility, and Negativity

Kavli Affiliate: Frank Wilczek | First 5 Authors: Frank Wilczek, , , , | Summary: Many widely different problems have a common mathematical structure wherein limited knowledge lead to ambiguity that can be captured conveniently using a concept of invisibility that requires the introduction of negative values for quantities that are inherently positive. Here I […]


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The Effectiveness of Security Interventions on GitHub

Kavli Affiliate: Felix Fischer | First 5 Authors: Felix Fischer, Jonas Höbenreich, Jens Grossklags, , | Summary: In 2017, GitHub was the first online open source platform to show security alerts to its users. It has since introduced further security interventions to help developers improve the security of their open source software. In this study, […]


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The Effectiveness of Security Interventions on GitHub

Kavli Affiliate: Felix Fischer | First 5 Authors: Felix Fischer, Jonas Höbenreich, Jens Grossklags, , | Summary: In 2017, GitHub was the first online open source platform to show security alerts to its users. It has since introduced further security interventions to help developers improve the security of their open source software. In this study, […]


Continue.. The Effectiveness of Security Interventions on GitHub

The Effectiveness of Security Interventions on GitHub

Kavli Affiliate: Felix Fischer | First 5 Authors: Felix Fischer, Jonas Höbenreich, Jens Grossklags, , | Summary: Since 2017, GitHub has been the first online open source platform to show security warnings to its users. It has since introduced further security interventions to help developers improve the security of their open source software. In this […]


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Bridging two quantum quench problems — local joining quantum quench and Möbius quench — and their holographic dual descriptions

Kavli Affiliate: Masahiro Nozaki | First 5 Authors: Jonah Kudler-Flam, Masahiro Nozaki, Tokiro Numasawa, Shinsei Ryu, Mao Tian Tan | Summary: We establish an equivalence between two different quantum quench problems, the joining local quantum quench and the M"obius quench, in the context of $(1+1)$-dimensional conformal field theory (CFT). Here, in the former, two initially […]


Continue.. Bridging two quantum quench problems — local joining quantum quench and Möbius quench — and their holographic dual descriptions